Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
… and therapeutic efficacy in a hamster model of SARS-CoV-2 … be quickly elicited during natural
SARS-CoV-2 infection or by … ab1 has potential for therapy and prophylaxis of SARS-CoV-2 …

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

S Wang, Y Peng, R Wang, S Jiao, M Wang… - Nature …, 2020 - nature.com
… needs for COVID-19 therapy as no SARS-CoV-2-specific drugs … and therapeutic efficacy of
MW05/LALA on SARS-CoV-2 in … -based therapies for prophylactic and therapeutic treatment …

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Z Zhang, E Zeng, L Zhang, W Wang, Y Jin, J Sun… - Cell Discovery, 2021 - nature.com
… of antiviral therapies as we previously described 5 . Here we adopted this animal model for
evaluation of hACE2-Fc prophylactic and therapeutic efficacy against SARS-CoV-2 infection …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
… recommended therapeutic agents, … therapeutic activity. The results of recent studies report
that hydroxychloroquine and convalescent plasma demonstrate no efficacy against SARS-CoV

Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus

CA Omolo, N Soni, VO Fasiku, I Mackraj… - European Journal of …, 2020 - Elsevier
… be targeted by therapeutic agents for treatment of SARS-CoV-2 … treatment, while oxygen
therapy is employed for intervention in … drugs/therapeutic agents and treatment for SARS-CoV-2 …

SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
… In conclusion, the main therapeutic advance during the pandemic has been the development
of highly potent neutralizing MAbs for the prevention and treatment of SARS-CoV-2. The …

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
… we assessed the in vivo therapeutic activity of another neutralizing anti-SARS-CoV-2 monoclonal
antibody … 8), demonstrate improved therapeutic efficacy compared with wild-type IgG1. …

Efficacy and safety of current therapeutic options for COVID-19-lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis

H Zhong, Y Wang, ZL Zhang, YX Liu, KJ Le… - Pharmacological …, 2020 - Elsevier
… The rapidly progressing of coronavirus disease 2019 (COVID-19) pandemic has become
a … efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS

… functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy …

CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
… generation and characterization of a highly efficacious anti-SARS-CoV-2 IgG1 neutralizing
antibody, SC31. Significantly, we show that the therapeutic efficacy of SC31 is not solely due …

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

J Huo, H Mikolajek, A Le Bas, JJ Clark… - Nature …, 2021 - nature.com
SARS-CoV-2 remains a global threat to human health … binding domain (RBD) of the
SARS-CoV-2 spike protein. Crystal … route showed potent therapeutic efficacy in the Syrian hamster …