Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu… - Nature …, 2021 - nature.com
… We reveal key cell type-specific transcription factors and major gene-regulatory circuits for
… critical stages and drivers of early kidney development 4 , that have been essential for the …

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development

M Hochane, PR van den Berg, X Fan… - PLoS …, 2019 - journals.plos.org
… of kidney diseases. In this paper, we present a single-cell transcriptomics study of the human
fetal kidney. … kidney development, easily accessible through an interactive web application. …

Mouse kidney development

AJ Davidson - African Scientist, 2019 - ojs.klobexjournals.com
… Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. …
genes encode repressors that control kidney development. Dev Biol. 2007;301:518–531. …

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Y Muto, PC Wilson, N Ledru, H Wu, H Dimke… - Nature …, 2021 - nature.com
… -seq can predict the transcription factors that drive cell-type-specificity, which may improve
our understanding of kidney development and directed differentiation of kidney organoids. We …

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk

AN Combes, B Phipson, KT Lawlor, A Dorison… - …, 2019 - journals.biologists.com
… We identify transcriptional congruence between the distal nephron and ureteric epithelium,
… Together, this work improves our understanding of metanephric kidney development and …

Developmental pathology of congenital kidney and urinary tract anomalies

S Jain, F Chen - Clinical kidney journal, 2019 - academic.oup.com
… is critical for normal kidney development, and this … (transcription factor) Hnf1β mutant mice
have severe hypoplasia and other kidney defects Broad expression in developing kidney and …

Molecular determinants of nephron vascular specialization in the kidney

DM Barry, EA McMillan, B Kunar, R Lis, T Zhang… - Nature …, 2019 - nature.com
… We identify several genes—including transcription factors and their putative targets that
define the ultrastructural, phenotypic, operational, and functional identity of the glomerular …

Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis

V Rudman-Melnick, M Adam, K Stowers, A Potter… - Scientific reports, 2024 - nature.com
… Genes shared between frTECs, distal tubule, loop of Henle and collecting duct included
kidney development (Cd24a, Sox4, Pkhd1) 51,52,54 , cell adhesion (Epcam, Lgals3, Ezr, Dag1) …

Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1

DR Little, KN Gerner-Mauro, P Flodby… - Proceedings of the …, 2019 - National Acad Sciences
… This study establishes NKX2-1 as a key transcription factor controlling AT1 cells. … genes
provides a foundation to unravel the transcriptional control of the poorly understood AT1 cell. …

Transcriptional control of brown and beige fat development and function

SN Shapira, P Seale - Obesity, 2019 - Wiley Online Library
… on the transcriptional and chromatin-… transcription factor A (MRTFA) induces myofibroblast-like
differentiation and blocks adipocyte development through stimulating the transcription of …