Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
… is more complicated than assays that measure antibody binding and virus neutralization. …
the roles of Fc-dependent antibody effector functions in the context of SARS-CoV-2 infection, …

Evaluation of antibody-dependent fc-mediated viral entry, as compared with neutralization, in sars-Cov-2 infection

L Wieczorek, M Zemil, M Merbah, V Dussupt… - Frontiers in …, 2022 - frontiersin.org
… of symptoms beyond the initial SARS-CoV-2 infection (4 or … plasma antibodies on inhibiting
or mediating SARS-CoV-2 entry … We determined that convalescent plasma antibodies could …

[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
… necessary for optimal Fc-dependent mAb protection … SARS-CoV-2-neutralizing monoclonal
antibodies (mAbs) isolated from the B cells of individuals with recent SARS-CoV-2 infection ( …

Deciphering Fc-effector functions against SARS-CoV-2

G Beaudoin-Bussières, A Finzi - Trends in Microbiology, 2024 - cell.com
Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections,
vaccinations, and breakthrough infections. … Thus, while Fc-dependent ADE remains to be …

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

CN Pierre, LE Adams, JS Higgins, K Anasti… - PLOS …, 2024 - journals.plos.org
… We hypothesized that Fc-mediated effector functions could protect against SARS-CoV-2
infection. … by Fc-dependent attachment of antibody-virus immune complexes led to hesitancy in …

Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity

KA Bowman, D Stein, S Shin, KG Ferbas, NH Tobin… - Mbio, 2022 - Am Soc Microbiol
infected with SARS-CoV-2 and 49 who were naive to … Thus, beyond improved levels of
neutralization (6) and T cell … of expanded non-neutralizing antibody Fc-effector function (28, 29). …

Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection

BM Gunn, S Bai - Human vaccines & immunotherapeutics, 2021 - Taylor & Francis
… thus clearing infected cells via Fc-dependent mechanisms in … the SARS-CoV-2 specific
non-neutralizing antibody CR3022 … functions that antibodies can mediate beyond neutralization. …

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

WS Lee, KJ Selva, SK Davis, BD Wines, A Reynaldi… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 re-infection, our results indicate that antibodieseffector functions persist longer
than neutralizing antibodies. … antibody function may extend the protective window beyond

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu… - Immunity, 2021 - cell.com
… of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase. Real-time …
Fc effector functions of NAbs are essential for optimal in vivo efficacy against SARS-CoV-2. …

Targeting Fc effector function in vaccine design

SI Richardson, PL Moore - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
… with SARS-CoV-2 28 days after initial infection and when … However, the generalizability of
these mechanisms beyond … the surface of healthy effector cells in an Fc-dependent manner […