LBA66 Efficacy and safety of nivolumab for patients with pre-treated type B3 thymoma and thymic carcinoma: Results from the EORTC-ETOP NIVOTHYM phase II trial

N Girard, SP Aix, S Cedres, T Berghmans… - Annals of …, 2021 - annalsofoncology.org
… trial evaluating the use of nivolumab (240 mg IV Q2 weeks) +/- ipilimumab (1mg /kg IV Q6
weeks) in patients (pts) with advanced/relapsed type B3 thymoma or thymic carcinoma, after …

Efficacy and safety of nivolumab for patients with pre-treated type B3 thymoma and thymic carcinoma: results from the EORTC-ETOP NIVOTHYM phase II trial

N Girard, SP Aix, S Cedres, T Berghmans, S Burgers… - ESMO open, 2023 - Elsevier
… that nivolumab could be a potential option more than routine standard of care in refractory
type B3 thymoma or thymic … Our efficacy figures are in line with other available treatments in …

Avelumab plus axitinib in unresectable or metastatic type B3 thymomas and thymic carcinomas (CAVEATT): a single-arm, multicentre, phase 2 trial

F Conforti, PA Zucali, L Pala, C Catania… - The Lancet …, 2022 - thelancet.com
… We report the efficacy and safety results of the combination … in patients with advanced type
B3 thymoma and thymic … -PD-1 drugs (ie, nivolumab, pembrolizumab, and avelumab) and two …

Current treatment approaches for thymic epithelial tumors

A Tartarone, R Lerose, AR Lettini, M Tartarone - Life, 2023 - mdpi.com
… in the same patient population, the anti-PD-1 nivolumab did not achieve the same efficacy
… In the CAVEATT study 32 pre-treated patients (27 thymic carcinoma, 3 thymoma B3, 2 mixed…

Therapeutic options in thymomas and thymic carcinomas

Y Muto, Y Okuma - Expert Review of Anticancer Therapy, 2022 - Taylor & Francis
thymic malignancies are rare cancers, the efficacy and safety … for previously treated type B3
thymoma and thymic carcinoma, … PFS of nivolumab monotherapy was met in 35% of patients. …

[HTML][HTML] Systemic treatments for thymic tumors: a narrative review

PA Zucali, F De Vincenzo, M Perrino, N Digiacomo… - Mediastinum, 2021 - ncbi.nlm.nih.gov
… and of patients with completely resected type B2 or B3 tumors … months in 32 patients with
cisplatin pre-treated thymoma (26). … II trial tested nivolumab as second line in patients with TC. …

Balancing the risk of adverse events against the efficacy of immunotherapy in advanced thymic epithelial tumors

B Ohm, W Jungraithmayr - Cancers, 2022 - mdpi.com
… Currently, combination therapy of Nivolumab and the anti-CTLA4-antibody … recurrent B3
thymoma or thymic carcinoma in the NIVOTHYM trial [13]. In the trial cohort receiving Nivolumab

Immunotherapy for Thymomas and Thymic Carcinomas: Current Status and Future Directions

A Rajan, AK Sivapiromrat, MJ McAdams - Cancers, 2024 - mdpi.com
Efficacy and safety of nivolumab for patients with pre-treated type B3 thymoma and thymic
carcinoma: Results from the EORTC-ETOP NIVOTHYM phase II trial. ESMO Open 2023, 8, …

[HTML][HTML] Efficacy and safety of treatments for advanced thymic carcinoma after failure of first-line platinum-based chemotherapy: A systematic literature review and …

A Arunachalam, I Zhang, B Zhao, AM Frederickson… - Lung Cancer, 2023 - Elsevier
… This review identified 19 trials evaluating 335 advanced thymic carcinoma patients. … In
the nivolumab trial, two patients (13 %) were reported with serious irAEs requiring hospital …

Pembrolizumab in a patient with heavily pre-treated squamous cell Thymic carcinoma and cardiac impairment: a case report and literature review

A Cafaro, A Bongiovanni, V Di Iorio, D Oboldi… - Frontiers in …, 2020 - frontiersin.org
… in patients with advanced thymoma treated with at least one prior standard therapy. Of the 7
patients with B1–B3 thymoma, … to investigate the efficacy and safety anti PD-1/PD-L1 drugs. …