HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human and mouse transcription factors

IE Vorontsov, IA Eliseeva, A Zinkevich… - Nucleic Acids …, 2024 - academic.oup.com
HOCOMOCO v12, which was rebuilt from scratch utilizing in vivo and in vitro high-throughput
data on TF bindingcuration, we assembled an updated catalog of binding motifs for 949 …

Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407

A Charrier, J Ockunzzi, L Main, SV Ghanta… - Plos one, 2024 - journals.plos.org
… PB) was extracted from the Hocomoco database v12 [37]. … DNA binding motifs across
species [36], the proposed human ZNF407 DNA binding motif was searched for within our murine

Methods for Functional Characterization of Genetic Polymorphisms of Non-Coding Regulatory Regions of the Human Genome

AN Uvarova, EA Tkachenko, EM Stasevich… - Biochemistry …, 2024 - Springer
Mouse models were used to demonstrate low off-target activity of prime editing when … -specific
TF binding with allele variants in different types of cells, is based on the HOCOMOCO and …

[PDF][PDF] universalmotif: An R package for biological motif

BJM Tremblay - raw.githubusercontent.com
… two main goals: to serve as a go-between for most common 11 biological motif programs
and Bioconductor packages used by the research community, and to 12 provide a robust set of …

Genomic background sequences systematically outperform synthetic ones in de novo motif discovery for ChIP-seq data

VV Raditsa, AV Tsukanov, AG Bogomolov, VG Levitsky - bioRxiv, 2024 - biorxiv.org
… from a recent study for mouse and human as examples (54). … in the foreground set is not due
to binding of specific TFs, but … the most reliable and popular, the HOCOMOCO (10), CisBP (…

Human transcription factor combinations mapped by footprinting with deaminase

R He, W Dong, W Ma, Z Wang, L Gao, C Xie, D Li… - bioRxiv, 2024 - biorxiv.org
… , such as JASPAR (22) and HOCOMOCO (23), which collected vast amounts 121 of …
Hocomoco in 2024: A rebuild of the curated collection of binding 467 models for human and mouse

[HTML][HTML] Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programs

M Minaeva, J Domingo, P Rentzsch, T Lappalainen - bioRxiv, 2024 - ncbi.nlm.nih.gov
… For each specific cell line, we curated relevant knockout experiments from the KnockTF2 …
promoters of target genes with TF binding sites (TFBS) from HOCOMOCO ( 23 ) and CIS-BP …

Nighttime-specific gene expression changes in suprachiasmatic nucleus and habenula are associated with resilience to chronic social stress

D Chaudhury, P Narain, A Petković, M Šušićb… - 2024 - researchsquare.com
HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human
and mouse transcription factors… Nucleic Acids Research 2024; 52: D154–D163. …

Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements

HE Pratt, G Andrews, N Shedd, N Phalke, T Li… - Science …, 2024 - science.org
… using the HOCOMOCO collection of 401 TF-binding motifs (64) … We curated four scATAC-seq
datasets to understand the cell … (We discarded the 1381 mouse-only VISTA regions in our …

MICA: a multi-omics method to predict gene regulatory networks in early human embryos

G Alanis-Lobato, TE Bartlett, Q Huang… - Life Science …, 2024 - life-science-alliance.org
human embryos at the late blastocyst stage to identify potential transcription factor (TF)
binding … We next manually curated a list of gene sets representing the most relevant pathways …