… examined the antiviral potential of exogenous human IFN-λ1 in cellular models of viral
infection. … According to our results, human IFN-λ1 has the potential to limit the replication of RNA …

… Hence, all of the selected viruses exhibited the ability to … , we showed that infection with
RNA viruses led to a significant … and IFIT1 displayed markedly elevated mRNA levels with IBV …

… viral growth in human fibroblasts and cortical neurons in vitro … (as measured by ELISA, which
recognizes all IFN-λ1/2/3 in a … encephalomyocarditis virus (EMCV), another RNA virus that …

… of ISGs in response to IFN-λ3 in vitro. Only upon TCR or PHA … While two previous studies
found IFN-λ1 or IFN-λ2 could … were isolated via FACS or magnetic selection. PBMCs or isolated …

… induced antiviral activity against enterovirus replication in vitro … Enteroviruses are
positive-sense single-stranded RNA viruses of … FIG 7 IFN-λ1 exerts antiviral activity against …

… (IFN-λ) displays potent antiviral activity against respiratory viruses and is … Human IFN-λ1
treatment was optimized in in vitro … We selected ISGs to test based on prior studies of mouse and …

… -3) interferons and selected antiviral peptides (ie, β-defensins 1-3, α-… coronaviruses and
common respiratory RNA viruses, SARS-CoV-2 is a poor inducer of IFN-I response in vitro and in …

… gene of human IFN-λ1 protein (hIFNλ1) which has antiviral and immunomodulatory … IFN-λ1
displays various levels of antiviral activity in vitro in a select panel of RNA viruses,” Viruses…

… (IL-6 and IL-8) and antiviral (IFN-λ1) cytokine production and the … propionate (FP) and selected
GR agonists GRT7 and GRT10 … in vitro evidence that a defective immune response to viral …

… common respiratory viruses in in vitro reconstituted human … Tissues were pretreated with
5 ng/ml of IFN-λ1 [the average … to one single respiratory virus were selected. After ethical …