Type I interferons and SARS-CoV-2: from cells to organisms

P Bastard, Q Zhang, SY Zhang, E Jouanguy… - Current Opinion in …, 2022 - Elsevier
… with SARS-CoV-2 in vitro produce low levels of type I IFNs, and … RNA virus from the
Coronaviridae family [11]. Seven … Finally, the administration of the type III interferon IFN-λ1

African swine fever virus B175L inhibits the type I interferon pathway by targeting STING and 2′ 3′-cGAMP

L Ranathunga, N Dodantenna, JW Cha… - Journal of …, 2023 - Am Soc Microbiol
… an antiviral role in response to DNA virus infection in vitro, we … , displayed heightened
levels of fluorescence and increased … ) was selected for further studies, and that selection was …

IFNλ: balancing the light and dark side in pulmonary infection

D Antos, JF Alcorn - Mbio, 2023 - Am Soc Microbiol
… another paper showing IFNλ-mediated inhibition of viral replication … Interestingly, IFNλ1 only
exerted antiviral activity in vitro … Simply select your manager software from the list below and …

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

N Te, J Rodon, M Ballester, M Pérez… - PLoS …, 2021 - journals.plos.org
… Despite that macrophages can be infected, at least in vitro, MERS… further expression of type
I interferons and IFN λ1 [31]. Therefore, … following infection by RNA viruses. Furthermore, the …

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and-λ

M Hayn, M Hirschenberger, L Koepke, JH Straub… - BioRxiv, 2020 - biorxiv.org
… Proteomics analysis of selected SARS-CoV-2 proteins … Taken together our analyses revealed
that IFN-γ and IFN-λ1 pathways … and in vitro infections with SARS-CoV-2, IFN-γ levels are …

Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding

J Yu, Y Dai, Y Fu, K Wang, Y Yang, M Li, W Xu, L Wei - Antiviral Research, 2021 - Elsevier
… In vitro antiviral assay showed that LL-37 and CRAMP … In order to determine if LL-37 and
CRAMP have antiviral activity … VP1 levels were examined by Western blot (C, upper panel) and …

Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider

A Burska, J Rodríguez-Carrio, R Biesen, WA Dik… - RMD open, 2023 - rmdopen.bmj.com
… This work will assist physicians and researchers to select the … This paper also described
criterion validity showing that … the cytopathic effect of viral replication on a target cell in vitro. …

Clinical Applications of Interferon (IFN) Signature Genes and Development of Assays in Small Blood Samples

B Huang - 2022 - search.proquest.com
… , I used the existing cohort to screen other gene biomarkers of … I selected the other 4
biochemical indicators with AUC … Type III interferons consist of four IFN-λ molecules called IFN-λ1, …

Pollen exposure weakens innate defense against respiratory viruses

S Gilles, C Blume, M Wimmer, A Damialis… - Allergy, 2020 - Wiley Online Library
… The effect of APE on the PolyIC-induced IFN-λ1 (IL-29) … On day 6, we restimulated total lung
cells in vitro with RSV-… -stranded RNA virus, activates an innate antiviral response involving …

Manganese enhances DNA-or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

H Sui, Q Chen, J Yang, S Srirattanapirom, T Imamichi - Iscience, 2022 - cell.com
… (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production. Microarray
… -1 (DNA virus) or Sendai virus (RNA virus) into human macrophages by enhancing antiviral