… the central nervous system (CNS). Therefore, GLP-1RAs need to pass through the blood-brain
barrier to exert their pharmacological effects. … Despite extensive research into the central …

… Specifically, disruption of the blood-brain barrier (BBB) is a critical pathologic process of
EBI and shows promise as a therapeutic target in ameliorating the detrimental effects of SAH (…

… While brain-derived GLP-1 may participate in these central … Using an artificially assembled
blood brain barrier consisting of … We conclude that GLP-1 crosses the blood brain barrier …

… Despite their distinct modes of action, both factors share pathways by regulating the central
… homeostasis and hedonic eating in the CNS via blood–brain barrier (BBB), research on the …

… pass the blood-brain barrier (… central insulin resistance should be differentiated from
peripheral resistance. Accordingly, some researchers have named the association between central …

… Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate
metabolism. It can cross the blood-brain barrier, … The wide distribution of glucagon-like peptide 1 …

… , including areas that are central for memory and cognition, such as the hippocampus and
frontal cortex 4, 5 (ii) peripheral insulin may cross the blood-brain barrier (most notably in …

… Cerebral blood vessel impairment is considered the main cause of … Recently, researchers
have focused on the relation between … inflammation and blood–brain barrier breakdown. ( 97 ) …

… including improving peripheral insulin sensitivity, improving central function such as
memory, and restoring a dysregulated blood-brain barrier (BBB). Central nervous system (CNS) …

… peptides whose respective receptors are also located in the central nervous system. Among
these peptides, the glucagon-like peptide-1 (GLP-1), which is secreted by pancreatic cells ( …