A TREM2‐activating antibody with a blood–brain barrier transport vehicle enhances microglia function
PE Sanchez - Alzheimer's & Dementia, 2023 - Wiley Online Library
Background Loss‐of‐function variants of TREM2 are associated with increased risk of
Alzheimer's disease (AD), suggesting that activation of this innate immune receptor may be
a useful therapeutic strategy. Method Here we describe a high‐affinity human TREM2‐
activating antibody engineered with a monovalent transferrin receptor (TfR) binding site,
termed antibody transport vehicle (ATV), to facilitate blood–brain barrier transcytosis. Result
Upon peripheral delivery in mice, ATV: TREM2 showed improved brain biodistribution and …
Alzheimer's disease (AD), suggesting that activation of this innate immune receptor may be
a useful therapeutic strategy. Method Here we describe a high‐affinity human TREM2‐
activating antibody engineered with a monovalent transferrin receptor (TfR) binding site,
termed antibody transport vehicle (ATV), to facilitate blood–brain barrier transcytosis. Result
Upon peripheral delivery in mice, ATV: TREM2 showed improved brain biodistribution and …
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's
disease (AD), suggesting that activation of this innate immune receptor may be a useful
therapeutic strategy. Here we describe a high-affinity human TREM2-activating antibody
engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody
transport vehicle (ATV), to facilitate blood–brain barrier transcytosis. Upon peripheral
delivery in mice, ATV: TREM2 showed improved brain biodistribution and enhanced …
disease (AD), suggesting that activation of this innate immune receptor may be a useful
therapeutic strategy. Here we describe a high-affinity human TREM2-activating antibody
engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody
transport vehicle (ATV), to facilitate blood–brain barrier transcytosis. Upon peripheral
delivery in mice, ATV: TREM2 showed improved brain biodistribution and enhanced …
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