Protein-directed dynamic combinatorial chemistry: an efficient strategy in drug design

A Canal-Martín, R Pérez-Fernández - ACS omega, 2020 - ACS Publications
… Protein-directed dynamic combinatorial chemistry (PD DCC) has evolved as a powerful and
… place in a thermodynamic controlled chemical system (dynamic combinatorial library, DCL) …

Topological methods for analysis and design of coordination polymers

EV Alexandrov, AP Shevchenko… - Russian chemical …, 2022 - iopscience.iop.org
chemistry with methods for topological design of polymer compounds, are considered.
Reticular chemistry methods are illustrated with examples of the analysis and design of …

Combinatorial assembly and design of enzymes

R Lipsh-Sokolik, O Khersonsky, SP Schröder… - Science, 2023 - science.org
The design of structurally diverse enzymes is constrained by long-range interactions that are
necessary for accurate folding. We introduce an atomistic and machine learning strategy for …

Fuel-driven dynamic combinatorial libraries

CME Kriebisch, AM Bergmann… - … the American Chemical …, 2021 - ACS Publications
… of a dynamic combinatorial library in response to a batch of chemical energy, which allowed
… To mimic better the complexity of chemical reaction networks in biology, we designed

Operads for complex system design specification, analysis and synthesis

JD Foley, S Breiner… - Proceedings of the …, 2021 - royalsocietypublishing.org
organization. Here, the whole is the root, the parts are the leaves, and each tree is an
organizational … We can mix, match and combine such combinatorial data to define different …

[HTML][HTML] From One to Millions: The Revolution of Combinatorial Chemistry

S Talreja, S Tiwari - … of Analytical Techniques and Research, 2024 - fortuneonline.org
combinatorial chemistry in the field of drug discovery [1,2]. … chemical compounds to identify
those with desirable properties. The principles of combinatorial chemistry involve the design

Recent advances in the transdermal delivery of protein therapeutics with a combinatorial system of chemical adjuvants and physical penetration enhancements

YH An, MJ Park, J Lee, J Ko, SH Kim… - Advanced …, 2020 - Wiley Online Library
… In this review, the techniques of both chemical and physical enhancement methods are …
lateral organization and the lamellar organization of the lipids. C) Lateral molecular organization

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase

RP Jumde, M Guardigni, RM Gierse, A Alhayek… - Chemical …, 2021 - pubs.rsc.org
… building blocks to cover a wide chemical space with good structural diversity… chemistry
approach driven by structure–activity relationships. Contrary to the traditional medicinal chemistry

A Tumor‐Targeting Metal‐Organic Nanoparticle Constructed by Dynamic Combinatorial Chemistry toward Accurately Redressing Carcinogenic Wnt Cascade

T Liu, J Yan, C He, W You, F Ma, Z Chang, Y Li, S Han… - Small, 2022 - Wiley Online Library
… Herein, a “one-pot” self-assembled strategy based on dynamic combinatorial chemistry (DCC)
principle is designed to construct a tumor-targeting metal-organic nanoparticle (MOICP) …

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform

WE Arter, R Qi, NA Erkamp, G Krainer, K Didi… - Nature …, 2022 - nature.com
… process underlying the organisation of the intracellular space … To address this challenge,
we present here a combinatorial … , multi-dimensional analysis of chemical space in the context …