Association of body mass index with colorectal cancer risk by genome-wide variants

PT Campbell, Y Lin, SA Bien… - JNCI: Journal of the …, 2021 - academic.oup.com
Body mass index (BMI) is a complex phenotype that may interact with genetic variants to
influence colorectal cancer risk. … identified by genome-wide association studies (GWAS) …

[PDF][PDF] Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes

GM Leyden, CY Shapland, GD Smith… - … of Human Genetics, 2022 - cell.com
… -scale genome-widemethod retains SNPs that have the strongest independent association
with BMI across the genome to identify the number of loci where genetic variation influences

The relative contributions of socioeconomic and genetic factors to variations in body mass index among young adults

R Kim, AM Lippert, R Wedow… - American Journal of …, 2020 - academic.oup.com
genome-wide polygenic score for BMI to explaining variation in … , researchers identified 97
BMI-associated loci accounting for … of socioeconomic factors and genetic variants in relation to …

Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians

AK Giri, G Prasad, K Bandesh, V Parekatt… - Molecular Genetics and …, 2020 - Springer
… adiposity for a given body weight compared to matched … specific genetic and environmental
factors influencing obesity… of a large genetic study to identify genetic variations regulating …

GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer

S Christakoudi, E Evangelou, E Riboli, KK Tsilidis - Scientific reports, 2021 - nature.com
… for body mass index (BMI), while allometric indices are … first genome-wide association study
of A Body Shape Index (… patterns of genetic variants identified for anthropometric indices with …

Genomics and phenomics of body mass index reveals a complex disease network

J Huang, JE Huffman, Y Huang, Í Do Valle… - Nature …, 2022 - nature.com
… The study of the genetic association of BMI across a broad range … We identify 906 (364 novel)
and 41 (6 novel) genome-wide … In summary, we harnessed genetic variation discovered in …

Transcriptome-wide association study identifies multiple genes associated with childhood body mass index

S Yao, H Wu, JM Ding, ZX Wang, T Ullah… - International journal of …, 2021 - nature.com
… utilities in revealing susceptibility genetic variants for BMI. The … the identified genes only
have a predominant influence on … Genome-wide association analysis identifies three new …

Pleiotropic genomic variants at 17q21. 31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis

XT Wei, GJ Feng, H Zhang, Q Xu, JJ Ni… - … of Human Genetics, 2021 - nature.com
… Aiming to identify pleiotropic genes underlying obesity and … Body mass index (BMI, kg/m 2
), defined as body weight divided by … genes may exist to influence the risks of both diseases. …

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

LO Huang, A Rauch, E Mazzaferro, M Preuss… - Nature …, 2021 - nature.com
… for regulatory variants that influence nearby genes that affect … of loci previously identified in
GWAS for body fat percentage (… association with lower lean mass (fat-free mass index; −0.01 …

The role of genetic variation of BMI, body composition, and fat distribution for mental traits and disorders: a look-up and Mendelian randomization study

T Peters, L Nüllig, J Antel, R Naaresh, BH Laabs… - … in genetics, 2020 - frontiersin.org
identified a large number of genome-wide significant loci with an impact on body mass index
(BMI; kg/m 2 )/obesity, body … (SNP) has a large influence on the regression coefficients, we …