… gene regulation at the single-cell level. … or how gene activity or expression is modulated
in response to stimuli, we can obtain a unique and dynamic perspective of gene regulation. …

… control mechanisms. Single molecule tracking (SMT) … in the physiological context of the
living cell. Here we review SMT principles, and discuss key TF properties uncovered by live-cell …

… value in a wide range of physiological settings. These … metabolism in addition to
transcriptional control to achieve … As enumerated in the above sections, predictive modelling has …

… important in understanding some aspect of cell physiology. The model may be relatively simple,
… To connect this abstract mathematical notion to cell physiology we must recognize that a …

… concentration is fundamental to cell physiology. While the number of transcripts of a given …
in single cells, including pathways not previously implicated in transcriptional control. However…

… key roles in transcription regulation that are not yet fully understood. The emerging model is
that … Furthermore, in situ studies are necessary to recapitulate physiological chromatin states …

… universal gene regulatory motif that produces robust perfect adaptation for mammalian cells,
… The importance of homeostasis is clearly exemplified in physiology and medicine, where a …

… Gene expression is central to all living systems and subject to a complex regulation all the
way from RNA synthesis to … Transcriptional initiation is the most important point of control in the …

… The simplest building blocks of gene circuits are the self-regulators: self-activators and
self-repressors. The corresponding gene regulation processes comprise several kinds of …

… The logistic regression is a widely used method of inferring predictive models in processes
… control of the transcriptional time window, the model probes the impact of each transcription …