Aging and influenza vaccine-induced immunity

HL Dugan, C Henry, PC Wilson - Cellular immunology, 2020 - Elsevier
immunity to influenza viruses, we review our current understanding of the effects of aging on
adaptive immune responses to influenza and discuss current and future avenues of vaccine

Influence of immune aging on vaccine responses

CE Gustafson, C Kim, CM Weyand… - … and Clinical Immunology, 2020 - Elsevier
… Below we detail current mechanistic understanding of age-related changes in T cells, as
well as discuss those in B cells, that may account for these alterations in older individuals. …

Understanding immunosenescence and its impact on vaccination of older adults

JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
vaccination. This review addresses current knowledge of age-related changes that affect
vaccine … humoral and cell-mediated immune responses, current vaccination schedules for …

[HTML][HTML] Targeting inflammation and immunosenescence to improve vaccine responses in the elderly

B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
aging and certainly affect vaccination. Likewise, age-related changes in the innate immune
system may have important consequences on antigen presentation and priming of adaptive …

Age-related changes in B cells relevant to vaccine responses

DK Dunn-Walters, AT Stewart, EL Sinclair… - Vaccines for Older …, 2020 - karger.com
Older people have reduced immune responses to infection and vaccination. B cell … ,
some of these changes may be due to age-related changes in accessory cells/signals. Other …

Agerelated factors that affect B cell responses to vaccination in mice and humans

D Frasca, BB Blomberg, D Garcia… - Immunological …, 2020 - Wiley Online Library
… summarize published results on age-related changes in response to … how aging affects the
response to the influenza vaccine with a … associated with aging lead to immune dysfunction. …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
… -aging as they pertain to age-related physiologic changes in the immune system, and how
these influence the host immune … how aging impacts the innate and adaptive immune systems …

[HTML][HTML] Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

DA Collier, IATM Ferreira, P Kotagiri, RP Datir, EY Lim… - Nature, 2021 - nature.com
immune responses following vaccination with the BNT162b2 mRNA vaccine 2 in elderly
We conclude that the elderly are a high-risk population and that specific measures to boost …

[HTML][HTML] Sex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults

JR Shapiro, H Li, R Morgan, Y Chen, H Kuo, X Ning… - npj Vaccines, 2021 - nature.com
immunity in this highly vaccinated older adult population and suggest that older males
are particularly vulnerable to reduced pre-existing humoral immunity to influenza. … Age-related

[HTML][HTML] Aging of the immune system: research challenges to enhance the health span of older adults

L Haynes - Frontiers in aging, 2020 - frontiersin.org
… the impacts of aging is the immune system, with age-related changes in immunity being
responsible … diseases and a decrease in the effectiveness of vaccinations. In addition, the innate …