… Studies have also shown that aged mice (>20 months of age) have … immune processes in
the elderly might lead to autoimmunity and inflammation [36]. A decrease in DCs and changes …

… In the aged immune system, an initial ineffective innate immune response leads to poor
viral clearance and greater viral replication. High levels of infected cells drive increased …

… Age-related remodeling of innate immunity modifies the homeostasis of NK cells, neutrophils,
and monocytes/macrophages (24). NK cells from the elderly exhibit impaired perforin …

… a lower homeostatic reserve due to an age-related multisystem physiological change. People
over 60, … Moreover, the age-related dysregulation of the immune system in the elderly (ie, …

… the immune response to RSV in older adults that require further study, it is clear that age-related
changes in the immune … the development of any vaccine-mediated immunity to RSV and …

… In the following sections, we describe selected tissues that exhibit strong age-related
alterations and discuss how these might impact innate immunity and vaccine efficacy. …

… We will thus discuss the changes in immunity in the older population and the consensual
changes … The association between age-related changes in regulation of immune response and …

… To do this, we must investigate the implications of aging on the innate and adaptive immune
… drive the aging process. We will summarize findings on age-related immune dysfunction to …

… aging, cellular senescence, and inflammaging have different effects on different cell-types,
identification of age-related changes in the innate and adaptive immune … a specific effect on …

… multiple changes in its immunobiology. Recent studies have shown that age-related changes
… We will also discuss these aspects as they relate to the aging process. All these facets are …