Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
older adults.79 ADE is a phenomenon that also needs to be considered in the development
of vaccines, … A second age-related change in the immune system is inflammaging, a chronic …

Age-related framing effects: Why vaccination against COVID-19 should be promoted differently in younger and older adults.

A Reinhardt, C Rossmann - Journal of Experimental Psychology …, 2021 - psycnet.apa.org
… is an important tool to help us get back to normal; however, the majority of the public must
be willing to get vaccinated to reach herd immunity. By considering postulates of message …

Immune system and COVID-19 by sex differences and age

T Ciarambino, O Para, M Giordano - Women's Health, 2021 - journals.sagepub.com
… is accompanied by a reduction in the size of the peripheral B cell pool, with CD19 + B cells
significantly lower in older adults.27 Some authors have reported an age-related increase in …

Agerelated differences in the immune response could contribute to determine the spectrum of severity of COVID‐19

G Costagliola, E Spada… - Immunity, inflammation …, 2021 - Wiley Online Library
age-related differences between adult and pediatric patients and the deriving clinical
implications. … Furthermore, aging is accompanied by remodeling of the immune system; with time, …

The conundrum of human immune system “senescence”

G Pawelec, A Bronikowski, SC Cunnane… - Mechanisms of ageing …, 2020 - Elsevier
… and implications. Here, we argue that only those differences in immune parameters between
younger and older adults … Moreover, this unbiased technology will provide an age-related

[HTML][HTML] Vaccine-induced ICOS+ CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

RS Herati, LV Silva, LA Vella, A Muselman… - Cell Reports …, 2021 - cell.com
aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective
humoral immunity… before and after influenza vaccination in young and elderly adults. First…

[HTML][HTML] Better response to influenza virus vaccination in physically trained older adults is associated with reductions of cytomegalovirus-specific immunoglobulins as …

ES Felismino, JMB Santos, M Rossi… - … in Immunology, 2021 - frontiersin.org
older population; particularly, the influenza virus is the main cause of the increased age-related
In this sense, it is widely accepted that the annual vaccination campaign for the influenza …

[HTML][HTML] Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond

B Weinberger - Immunity & Ageing, 2021 - Springer
… Europe towards a much older population. Between 2010 and … Preserving good health in old
age is of utmost importance to … on vaccines to prevent infectious disease in older adults. The …

[HTML][HTML] Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity

R Channappanavar, S Perlman - The Journal of clinical …, 2020 - Am Soc Clin Investig
… and agedage-related severe disease. We also highlight the existing gaps in our knowledge
about virus replication and host immune responses to hCoV infection in young and aged

[HTML][HTML] The untwining of immunosenescence and aging

W Xu, G Wong, YY Hwang, A Larbi - Seminars in immunopathology, 2020 - Springer
… , we propose to disentangle the senescence of immune cells from chronological aging. …
linked to the age-related changes and loss of motor neurons in the motor unit. With aging, motor …