Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease
despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to
the pathogenesis of DKD although the majority of investigative efforts have focused on the
glomerulus. We sought to examine the differential expression signature of human DKD in
the glomerulus and proximal tubule and corroborate our findings in the db/db mouse model
of diabetes. A transcriptogram network analysis of RNAseq data from laser microdissected …