In this paper, the impact of varying path loss exponent (PLE) on user association probability, decoupled uplink coverage probability as well as decoupled uplink average spectral efficiency in downlink uplink decoupled (DUDe) multi-tier heterogeneous networks, is investigated. We investigate the effect of the difference in path loss exponents in both macro and small cell environments over uplink network performance. It is assumed that the mobile user connected to the macro base station experience different path loss exponent as compared to when connected to small base station. It is observed that the difference of path loss exponents in both cases has significant effect on the user association probability, decoupled uplink coverage probability as well as decoupled uplink average spectral efficiency. Moreover, in order to further support key findings and make sound comparison between coupled and DUDe performance in varying PLE environment, generalized analytical expressions for coupled association probabilities, along with coupled uplink coverage probability and coupled uplink average spectral efficiency have been derived. The analytical results evaluated in this paper are compared with the computer simulation and found in good agreement. Our analysis shows that decoupling technique performs suboptimal for cases where the environments around macro and small base stations are different with respect to each other. The work explained in this paper highlights the limitation of applying DUDe technique in realistic conditions where the PLEs of cellular tiers are not exactly equal to one another.