… Thus, drugs targeting hemozoin formation (a unique process by Plasmodium spp. to
detoxify free heme) remain a key and viable target for anti-malarial drug … mechanism yet [1]. …

… focus on drug inhibiting the β-hematin formation via π-π interactions, ie., by heme-drug
interactions. … Compound 42 f was subjected for mechanistic study, and it was observed that this …

… These metrics are regularly updated to reflect usage leading … docking to discover new
hemozoin inhibiting compounds from an … Our work on the mechanism of β-hematin formation has …

… -class antimalarials inhibit the formation of hemozoin and in … We show that these adducts
inhibit β-hematin crystallization … via parent drug activation. Our findings reveal an irreversible …

… biomineralization of hematin into hemozoin crystals, differing … A second mechanism, where
a drug binds by adsorption … –drug adducts to inhibit β-hematin crystal formation and the …

… in hemozoin. This is also the case of PYR which was found to be equally potent as chloroquine
at inhibiting β-hematin formation in … suppresses β-hematin crystal growth by a mechanism …

… These metrics are regularly updated to reflect usage leading … To study the role of CQ in
inhibiting heme to β-hematin … of chloroquine on hemozoin formation, and it is well-established that …

… These metrics are regularly updated to reflect … mechanism within its digestive vacuole
where the heme group is converted into a nontoxic crystalline solid called hemozoin (β-hematin), …

… the digestion of hemoglobin to release heme inhibited the activation of artemisinin, whereas
the … developed a detoxification mechanism that converts hematin to non-toxic hemozoin (…

… They can inhibit hemozoin biocrystallization and inhibit … mechanism of hemozoin
biocrystallization. Under the acidic condition inside the food vacuoles, β-hematin, a heme dimer …