[HTML][HTML] First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients

H Chen, Z Zhang, L Wang, Z Huang, F Gong, X Li… - Medicine, 2020 - journals.lww.com
… adverse outcomes during this study. After initiation of danoprevir/ritonavir treatment, the first
After 4 to 12-day treatment of danoprevir boosted by ritonavir, all enrolled 11 patients were …

[HTML][HTML] Influenza and antiviral resistance: an overview

T Lampejo - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
… was first recognised during the 1980 influenza A epidemic [12]. However, resistance to
both drugs in seasonal influenza A subtypes was rare (1–2% frequency) until after 2000 when …

[HTML][HTML] Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

BR Beck, B Shin, Y Choi, S Park, K Kang - Computational and structural …, 2020 - Elsevier
antiviral drugs identified by the MT-DTI model should be considered, when establishing
effective treatment … an FDA-approved drug, but regarded as a promising antiviral drug for SARS-…

[HTML][HTML] An update on current therapeutic drugs treating COVID-19

R Wu, L Wang, HCD Kuo, A Shannar, R Peter… - Current pharmacology …, 2020 - Springer
drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and
specific drugs … outcomes were observed after receiving antiviral treatment with oseltamivir [65]. …

SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19

I Vicenti, M Zazzi, F Saladini - Expert Opinion on Therapeutic …, 2021 - Taylor & Francis
… , a key antiviral drug approved for the treatment of Hepatitis C [Citation… antiviral initially
developed to combat Ebola virus and eventually approved under emergency use for the treatment

[HTML][HTML] Antiviral peptides: identification and validation

G Agarwal, R Gabrani - International journal of peptide research and …, 2021 - Springer
… by year. The peptide-based antiviral therapeutics have been approved for the Human … of
target for the designing of effective and safe antiviral drugs without harming the host cell, is an …

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

SS Good, J Westover, KH Jung, XJ Zhou… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
approved by the FDA to treat SARS-CoV-2 infection, no oral antiviral is available for outpatient
treatment. … , therefore, may lead to an effective antiviral treatment. A phase 2 clinical trial (…

Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID‐19

B Damle, M Vourvahis, E Wang… - Clinical …, 2020 - Wiley Online Library
… AZ is not approved for antiviral therapy but has been studied in vitro and in clinical trials for
… This review was undertaken to assess key AZ published data on in vitro antiviral activity and …

[HTML][HTML] Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

M Rogosnitzky, P Okediji, I Koman - Pharmacological Reports, 2020 - Springer
… Also, its low EC 50 and CC 50 achievable with oral dosing, and synergistic properties
when combined with other antiviral medications (such as nelfinavir and mefloquine), further …

[HTML][HTML] Potential antiviral options against SARS-CoV-2 infection

A Ianevski, R Yao, MH Fenstad, S Biza, E Zusinaite… - Viruses, 2020 - mdpi.com
… novel anti-SARS-CoV-2 developments and currently approved diagnostic options around
the globe. It also tracks the development of therapeutic/antiviral drugs and vaccines. …