Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities

R Cannalire, C Cerchia, AR Beccari… - Journal of medicinal …, 2020 - ACS Publications
… received the approval from the FDA for the treatment of … antiviral drugs for the treatment
of HIV and hepatitis C virus (HCV) infections and also allowed for the development of antiviral

Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
… was approved by the United States Food and Drug Administration (US FDA) in 1986, and
during this time, antibody engineering has dramatically evolved. Current antibody drugs have …

Rapid repurposing of drugs for COVID-19

RK Guy, RS DiPaola, F Romanelli, RE Dutch - Science, 2020 - science.org
… Since all drug discovery efforts have led to Gina which has sequence homology with …
approved HIV drug (4), it is only logical to explore enfuvirtide and other fusion inhibitors as drugs

Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis

W Liu, P Zhou, K Chen, Z Ye, F Liu, X Li, N He, Z Wu… - Cmaj, 2020 - Can Med Assoc
Antiviral medications are being given empirically to some patients with coronavirus disease
2019 (… review that addressed the benefits and harms of 7 antiviral treatments for COVID-19. …

Déjà vu: stimulating open drug discovery for SARS-CoV-2

S Ekins, M Mottin, PRPS Ramos, BKP Sousa… - Drug discovery today, 2020 - Elsevier
… Here, we propose, based on open antiviral drug discovery … approved drug is to take one
class of compounds. For example we have now taken the opportunity to dock FDA-approved HIV

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

L Chen, J Liang - Materials Science and Engineering: C, 2020 - Elsevier
… popular antiviral drug in clinical practice to treat diseases such as HBV and HCV [4]. Another
commonly used antiviral drug … , the nanoparticle drugs approved by the US Food and Drug

Identification of SARS-CoV-2 entry inhibitors among already approved drugs

L Yang, R Pei, H Li, X Ma, Y Zhou, F Zhu… - Acta Pharmacologica …, 2021 - nature.com
… have been used for decades and are safe, but it is unclear as to whether these approved
drugs have pharmacokinetics that are suitable for COVID-19 antiviral treatment, and we …

Multicenter initial guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2

K Chiotos, M Hayes, DW Kimberlin… - Journal of the …, 2020 - academic.oup.com
… <12 years, so antiviral use in children is largely limited to off-label prescribing of agents
approved by the Food and Drug … supports a benefit of antiviral treatment for pediatric patients with …

The challenge of HIV treatment in an era of polypharmacy

D Back, C Marzolini - Journal of the International AIDS Society, 2020 - Wiley Online Library
… the DDI potential of a drug is critical to ensure safety during clinical phase II and III studies,
as well as post approval. Additional studies may be required post-approval due to emerging …

[HTML][HTML] Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

H Pan, R Peto, AMH Restrepo, MP Preziosi… - The Lancet, 2022 - Elsevier
… These could be quickly donated by manufacturers and approved by many … treatment during
this episode with some other anti-viral drug(s), some effective immune-modulating drug(s), or …