[HTML][HTML] Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

E Shosha, AY Fouda, T Lemtalsi, S Haigh, D Fulton… - Molecular …, 2021 - Elsevier
… of the mitochondrial arginase isoform, arginase 2 (A2), limits … The damage was attributed
to increased oxidative stress, … of A2 limits the formation of acellular capillaries and prevents I/…

Is the arginase pathway a novel therapeutic avenue for diabetic retinopathy?

E Shosha, AY Fouda, SP Narayanan… - Journal of clinical …, 2020 - mdpi.com
… pathology, we still do not have an effective treatment to limit the … That study showed that
hyperoxia-induced neuronal cell … A2 prevented the SMOX activation, reduced the oxidative stress

Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair

AY Fouda, Z Xu, J Suwanpradid, M Rojas… - Cell Death & …, 2022 - nature.com
… In contrast with A1 deficiency, mice globally deficient in A2 … We next evaluated the effects
of PEG-A1 on hyperoxia-induced … on the retinal vasculature, OIR also induces retinal neuro-…

Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases

Z Li, L Wang, Y Ren, Y Huang, W Liu, Z Lv, L Qian… - Cell Death …, 2022 - nature.com
… in the cardiovascular system, particularly in ECs, will limit NO … be related with the increase
oxidative stress because of eNOS-… deletion prevents hyperoxia-induced retinal vascular injury, …

Role of Neuronal Spermine Oxidase in Vascular Damage in a Model of Ischemic Retinopathy

E Jafari - 2021 - search.proquest.com
… target to limit the progression of ischemic retinopathies. … to hypoxia harm the retinal neurons
as a result of oxidative stress. In … of Arginase 2 (A2) protected against hyperoxia induced

[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways

M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
… degeneration of ROP is oxidative stress dependent. … Nitric oxide synthase and arginase
play important roles in … Vasorepulsive molecules (semaphorin 3A) intervene preventing the …

Spermine oxidase inhibitor, MDL 72527, reduced neovascularization, vascular permeability, and acrolein-conjugated proteins in a mouse model of ischemic …

A Alhumaid, F Liu, S Shan, E Jafari, N Nourin… - Tissue …, 2024 - Taylor & Francis
… a potent inducer of oxidative damage serves as a significant … that retinal vascular degeneration
under hyperoxia-induced … , plays a crucial role in preventing apoptosis by interacting with …

Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB …

F Li, X Sun, B Zheng, K Sun, J Zhu, C Ji… - Frontiers in Cell and …, 2021 - frontiersin.org
deficiency inhibited senescence and apoptosis of NPCs, and degeneration of the ECM
induced by oxidative stress … Taken together, our results suggest that ARG2 deficiency prevents

Pharmacological inhibition of spermine oxidase reduces neurodegeneration and improves retinal function in diabetic mice

F Liu, AB Saul, P Pichavaram, Z Xu… - Journal of Clinical …, 2020 - mdpi.com
… of polyamines is elevated during hyperoxia-induced retinaloxidative stress resulting from
elevated polyamine oxidation. [… to limit neuronal damage and dysfunction in vision disorders. …

Retinopathy of Prematurity—Targeting Hypoxic and Redox Signaling Pathways

L Zhang, F Buonfiglio, A Fieß, N Pfeiffer, A Gericke - Antioxidants, 2024 - mdpi.com
… bovine retinal endothelial cells that hyperoxia-induced nitro-oxidative stress leads to retinal
arginase 2 might play a role in the events leading to retinal injuries, closely linked with nitro-…