… underlying endothelial dysfunction in diabetes and may serve … arginase as a key mediator
in endothelial dysfunction and … diseases, especially type 2 diabetes, atherosclerosis and …

… endothelial dysfunction in type 1 and type 2 diabetes (T1DM … effect of arginase inhibition
on vascular function, EDV and EIDV … 120 min intra-arterial infusion of the arginase inhibitor N …

… completely prevented the increase in arginase activity and … diabetic patients through
increasing NO levels and thus maintaining vascular function possibly through an arginase inhibition …

… of T2DM as well as in the plasma of patients with T2DM and microvascular complications [8,…
, shown that arginase inhibition improves endothelial function in several patient populations …

… Recently, it also has been reported to improve vascular function in diabetics by decreasing
arginase activity in cavernous tissue and raising NO levels [168]. L-norvaline has minimal …

… -dependent NOS-mediated dilation of retinal arterioles during diabetes, whereas … vascular
arginase may improve endothelial function of retinal arterioles during early onset of diabetes…

… from the eNOS to the arginase pathway with its enhanced arginase degradation, as an …
the downregulation of arginase improves endothelial function among patients with DM and …

… does not increase NO production or improve endothelial function. Conversely, the chronic
administration of L-arginine has been shown to increase the products of the arginase pathway…

… observed in diabetic group of rats was prevented by arginase inhibition, … endothelial function
in early and late Type 2 diabetes showed that 12 weeks of troglitazone treatment improved …

… vascular functions. It is well-established that, in mammals, arginase overactivation contributes
to endothelial dysfunction… potential of arginase inhibition for improving vascular function is …