… We divided lymphocytes into tumor-infiltrating lymphocytes (… high expression of PD-L1 or
PD-1, the number of CD8+ T cells … a relationship between clinicopathological features and PD-1/…

… Recent development in clinical applications of PD-1 and PD-… and tumor cell-intrinsic features,
such as PD-L1 expression status… We also explored the role of circulating CD8+ T cells from …

… PD-1+CD8+ T cells showed equivalent function to their PD-1… of an increased level of
PD-1+CD8+ T cells in tumors, we … have contributed to PD-1 expression on CD8+ T cells. TSN or …

… exhaustion status of CD8 + tumor-infiltrating lymphocytes (TILs… CD8 + TILs based on the
level of programmed cell death-1 (… of exhausted CD8 + TILs and their characteristics. We further …

… correlations between PD-1/PD-L1 and pathological features … revealed that higher expression
levels of CD3, CD4, CD8, and … marker of regulatory T cells. Some studies have indicated an …

… increased stepwise according to the level of PD1 expression on CD8 + T cells (Figure 3E), …
of differential PD1 expression on tumor-infiltrating CD8 + T cells. The gate to define the PD1 …

… In our study, CTLA-4 was expressed among CD8 + TILs, although the expression level was
… of the cellular response to PD-1 blockade in CD8 + TILs that functions in a different manner …

… L1 and PD-1 expressions in relation to the infiltration by CD8 + … close correlation between
infiltrating CD8 + and FOXP3 + T cells… an inhibitory function against effector T cells, and PD-1 is …

… features based on CD8 median expression are shown in Table 1, where it can be seen a clear
association between amount of CD8 lymphocytes … represented by CD8+ cytotoxic T cells, …

… the density of tumor-infiltrating CD4 + T cells expressing the … an improved response rate
and survival to PD-1 blockade (65… exhausted CD8 + T cells and PD-1 + CD38 hi CD8 + T cells …