Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis

B Li, Y Chen, F Wang, J Guo, W Fu, M Li, Q Zheng… - Oncogene, 2020 - nature.com
… To obtain the best experience, we recommend you use a more up to date browser (or turn
off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we …

Transcriptional regulators in stem cell biology

MM Wilson - 2022 - dspace.mit.edu
… BMI1 promotes self-renewal through yet other mechanisms in transformed mammary tissues.
Overexpression of Bmi1 in transformed mammary epithelial cells promotes expression of …

BMI1 is a Novel, Preclinical Target in Fusion-Positive Rhabdomyosarcoma

CE Shields - 2021 - search.proquest.com
… is associated with global epigenetic dysregulation. To restore … epithelial cells transition to
invasive mesenchymal cells that … that BMI1 collaborates with H-RAS to promote invasion and …

… Moloney murine leukaemia virus integration site 1 (BMI1) and CD44+/CD24−/low associates with poor clinicopathological features in African patients with breast …

E Gyan, WKBA Owiredu, LA Fondjo, AM Jackson… - Gene Reports, 2022 - Elsevier
… Their ability to dedifferentiate from epithelial to mesenchymal cells through EMT also make
Bmi-1 cooperates with H-ras to transform human mammary epithelial cells via dysregulation

[HTML][HTML] Polycomb repressor complex: Its function in human cancer and therapeutic target strategy

J Liu, H Fan, X Liang, Y Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
… implications of PRC complex dysregulation in various tumors, … with H-RAS to transform
breast epithelial cells [138]. … that elevated BMI-1 gene expression in squamous lung cell

[HTML][HTML] Interacting with tumor cells weakens the intrinsic clockwise chirality of endothelial cells

B Hang, E Jassem, H Mohammed, LQ Wan… - APL …, 2022 - pubs.aip.org
Using a micropatterning method, we assessed the EC … Finally, we found the chirality change
of ECs could result from … In this study, the MCF10A human breast epithelial cell line and …

[HTML][HTML] Senolytic therapy: a potential approach for the elimination of oncogene-induced senescent HPV-positive cells

T Saleh, AI Khasawneh, N Himsawi… - International Journal of …, 2022 - mdpi.com
… hence transformation, of cervical epithelial cells via several … preserve their active metabolic
status, albeit dysregulated, as … of H-Ras in WI-38 human fibroblasts renders these cells

[HTML][HTML] Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer …

GG Jinesh, AS Brohl - Signal transduction and targeted therapy, 2022 - nature.com
… is largely remodeled by dysregulated PRC2 complex-mediated … through multiple
mechanisms (including epithelial cell … , H-Ras, N-Ras, and others also play a role depending on …

[HTML][HTML] Dissection of the MKK3 functions in human cancer: a double-edged sword?

V Piastra, A Pranteda, G Bossi - Cancers, 2022 - mdpi.com
… in human cancer the consequences of its dysregulation in … as the SB203580 rescued Bmi-1
expression downregulating … untransformed cellular context (primary mammary epithelial cells

Micro-RNA: The darkhorse of cancer

M Budakoti, AS Panwar, D Molpa, RK Singh… - Cellular signalling, 2021 - Elsevier
… As with Drosha's knockdown, DGCR8's knockdown also facilitates cell transformation and …
of expression correlate with breast cancer risk [69]. XPO5 dysregulation thus results in miRNA …