Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis
XX Wang, GH Mao, QQ Li, J Tang, H Zhang… - Frontiers in …, 2023 - frontiersin.org
… protein levels of nitrotyrosine (marker of protein nitrification mediated by nitric oxide), 4-HNE
(… the relationship between the neuroprotection of NAD + or NBP and SIRT1 or SIRT3. The …
(… the relationship between the neuroprotection of NAD + or NBP and SIRT1 or SIRT3. The …
[HTML][HTML] … 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in …
… is a novel mechanism of MC1R-mediated neuroprotection in a rat model of … /SIRT1/PGC-1α
signaling pathway. The novel findings of this study were: (1) the protein expression of SIRT1 …
signaling pathway. The novel findings of this study were: (1) the protein expression of SIRT1 …
Sirt1 activity in the brain: Simultaneous effects on energy homeostasis and reproduction
S D'Angelo, E Mele, F Di Filippo, A Viggiano… - International journal of …, 2021 - mdpi.com
… the brain has been linked to brain aging, neuroprotection … central control of energy
homeostasis, modulation of circadian … or siRNA mediated knock down of hypothalamic Sirt1 [89]. …
homeostasis, modulation of circadian … or siRNA mediated knock down of hypothalamic Sirt1 [89]. …
The protective mechanism of SIRT1 in the regulation of mitochondrial biogenesis and mitochondrial autophagy in Alzheimer's disease
F Ye, A Wu - Journal of Alzheimer's Disease, 2021 - content.iospress.com
… SIRT1 is widely expressed in the brain and is involved in a variety of physiological activities
… brain function and mediate caloric restriction, exerting anti-aging and neuroprotective effects. …
… brain function and mediate caloric restriction, exerting anti-aging and neuroprotective effects. …
SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan
… concerned with the neuroprotective potential of SIRT1 and thus … SIRT1 plays a significant
role in metabolic homeostasis. … Arctigenin mediated SIRT1 activation in the middle cerebral …
role in metabolic homeostasis. … Arctigenin mediated SIRT1 activation in the middle cerebral …
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 …
H Song, Z Ding, J Chen, T Chen, T Wang… - Immunopharmacology …, 2022 - Taylor & Francis
… neuroprotective effect and mechanism of Hes on TBI-induced acute cerebral damage. …
In contrast, AMPK agonists can facilitate neuroprotection and improve memory in TBI rats [Citation…
In contrast, AMPK agonists can facilitate neuroprotection and improve memory in TBI rats [Citation…
Interplay between systemic glycemia and neuroprotective activity of resveratrol in modulating astrocyte SIRT1 response to neuroinflammation
AD Grabowska, M Wątroba, J Witkowska… - International Journal of …, 2023 - mdpi.com
… Here, we addressed the regulation of SIRT1 secretion by astrocytes within the blood–brain
barrier (BBB) in different glycemic backgrounds (hypo-, normo-, and hyperglycemia) in …
barrier (BBB) in different glycemic backgrounds (hypo-, normo-, and hyperglycemia) in …
The beneficial roles of SIRT1 in neuroinflammation‐related diseases
F Jiao, Z Gong - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
… anti-inflammatory and neuroprotective effects of SIRT1. First, … Thus, it is easy to understand
that SIRT1 mediates the … reported the neuroprotective benefits for cerebral ischemic …
that SIRT1 mediates the … reported the neuroprotective benefits for cerebral ischemic …
Relieving cellular energy stress in aging, neurodegenerative, and metabolic diseases, SIRT1 as a therapeutic and promising node
Y Fang, X Wang, D Yang, Y Lu, G Wei, W Yu… - Frontiers in Aging …, 2021 - frontiersin.org
… , namely autophagy-mediated down-regulation of mammalian SIRT1 protein during aging …
produce neuroprotective effects similar to resveratrol, reduce the content of Aβ in the brain of …
produce neuroprotective effects similar to resveratrol, reduce the content of Aβ in the brain of …
[HTML][HTML] The critical role of SIRT1 in Parkinson's disease: mechanism and therapeutic considerations
X Li, Y Feng, XX Wang, D Truong, YC Wu - Aging and disease, 2020 - ncbi.nlm.nih.gov
… /Akt1 signaling pathway was inhibited, the neuroprotective … implied that SIRT1 and Akt1 could
mediate neuroprotection and … SIRT1 has been shown to confer protection against cerebral …
mediate neuroprotection and … SIRT1 has been shown to confer protection against cerebral …