CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

HT Lu, RQ Feng, JK Tang, JJ Zhou, F Gao… - Cell Death & Disease, 2020 - nature.com
… to prevent Ca 2+ paradox-induced heart injury. In contrast, the … an essential element in
CaMKII-elicited calpain activation. In … Ca 2+ is not the unique factor governing calpain activity, as …

Pharmacological conditioning of the heart: an update on experimental developments and clinical implications

S Roth, C Torregroza, K Feige, B Preckel… - International journal of …, 2021 - mdpi.com
… The exact mechanism of this paradox is still underexplored. One … effects against myocardial
I/R injury by preconditioning with … rat heart I/R [69]. Similar results were observed in a working …

Endless Journey of Adenosine Signaling in Cardioprotective Mechanism of Conditioning Techniques: Clinical Evidence

K Kumar, N Singh, HN Yadav… - Current Cardiology …, 2023 - ingentaconnect.com
Ca2+ preconditioning elicits a unique protection against the Ca2+ paradox injury in rat heart.
Role of adenosine. Fixed… Calcium preconditioning elicits strong protection against ischemic …

A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation

PP Cullen, SS Tsui, NM Caplice… - … and thoracic surgery, 2021 - academic.oup.com
… The major modulating pathways have been elicited and, … Ischaemic preconditioning. A brief
period of reperfusion in … ROS production is impaired in its absence, but this is paradoxical as …

Mitochondrial quality control in cardiac-conditioning strategies against ischemia-reperfusion injury

WR García-Niño, C Zazueta, M Buelna-Chontal… - Life, 2021 - mdpi.com
… IPC elicits a bi-phasic pattern of cardioprotection. The first phase … In rats with myocardial
I/R injury, preconditioning or … The role of mitophagy in reperfusion injury is paradoxical, as …

Perioperative cardioprotection: general mechanisms and pharmacological approaches

C Torregroza, A Raupach, K Feige… - Anesthesia & …, 2020 - journals.lww.com
… The typical paradox of ischemic conditioning—a sublethal injury leads to … against I/R
injury by preconditioning with milrinone or levosimendan are fully abolished by propofol in rats. …

Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure

Y Gong, J Lin, Z Ma, M Yu, M Wang, D Lai, G Fu - Life Sciences, 2021 - Elsevier
… , excessive and unresolved UPR elicits uncontrolled cell death [76]. … Meanwhile, the protective
role of preconditioning … They went further to suggest that this paradox may be attributed to …

Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols

C Penna, I Andreadou, M Aragno… - British journal of …, 2020 - Wiley Online Library
… an increased preconditioning stimulus in diabetic hearts. This … of diabetes, the heart is in a
paradoxical state of protection. … to abrogate cardioprotection elicited by limb RIC in a rat acute …

[HTML][HTML] Ischemia preconditioning alleviates ischemia/reperfusion injury-induced coronary no-reflow and contraction of microvascular pericytes in rats

Q Li, Z Guo, C Wu, Y Tu, Y Wu, E Xie, C Yu, W Sun… - Microvascular …, 2022 - Elsevier
… Adenosine released during the precondition occlusion protected the heart against I/R injury
Ca2+ preconditioning elicits a unique protection against the Ca2+ paradox injury in rat heart. …

Nitrite and myocardial ischaemia reperfusion injury. Where are we now?

K Griffiths, JJ Lee, MP Frenneaux, M Feelisch… - Pharmacology & …, 2021 - Elsevier
… future for nitrite as a pre-conditioning intervention in man. … in a paradoxical phenomenon
termed myocardial ischaemia … intra-arterial infusions of nitrite elicit a substantial vasodilatory …