TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans

C Manzato, L Larini, C Oss Pegorar… - Nucleic Acids …, 2023 - academic.oup.com
… of DNA damage response pathways, degradation and erroneous recombination events (1). …
We show that TERRA expression is repressed by the telomere-binding proteins POT-1 and …

Identification of POT-3 and its role in telomere length maintenance in Caenorhabditis elegans

X Yu - 2024 - research-repository.st-andrews.ac …
telomerase-dependent telomere maintenance and acts as a 3’ to 5’ exonuclease. POT-1 and
POT-2 repress telomerase … act in the same telomere regulation pathway, display differential …

[HTML][HTML] The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1

…, N Viceconte, A Fradera-Sola, C Renz… - Nature …, 2021 - nature.com
… In the nematode Caenorhabditis elegans, a comprehensive … be in a pathway for facilitation
of telomere elongation together … support direct interactions between POT-1, POT-2, and MRT-1…

[PDF][PDF] Identification and characterization of novel telomere binding proteins in Caenorhabditis elegans

SF Dietz - 2020 - openscience.ub.uni-mainz.de
… reported single-strand telomere binders POT-1, POT-2 and MRT-… genes involved in the
telomerase maintenance pathway, and … POT-1 and POT-2 on the other hand work in repression of …

[HTML][HTML] Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

I Yamamoto, K Zhang, J Zhang, E Vorontsov… - Elife, 2021 - elifesciences.org
telomeric DNA-binding proteins POT-1 and POT-2 and constitutively localize to telomeres. …
and subsequent activation of the DNA-damage response pathway in the double KO worms. …

[HTML][HTML] Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations

EH Lister-Shimauchi, M Dinh, P Maddox… - Communications …, 2021 - nature.com
… The nematode Caenorhabditis elegans possesses four Pot1 genes … may function together
to repress telomerase. However, … elegans POT-1 or POT-2 single-stranded telomere binding …

POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang

X Yu, S Gray, HC Ferreira - Nucleic Acids Research, 2023 - academic.oup.com
… The nematode worm Caenorhabditis elegans contains three POT1-like proteins (POT-1,
POT-2 and … They both repress telomerase activity to prevent the inappropriate lengthening of …

[HTML][HTML] Genetic and epigenetic inheritance at telomeres

EH Lister-Shimauchi, B McCarthy, M Lippincott… - Epigenomes, 2022 - mdpi.com
elegans: POT-1 and POT-2, which repress telomerase … small RNA pathways were tested
for effects on telomeric foci, … of pot-1; pot-2 double mutants have very low levels of telomeric

[HTML][HTML] The Altered Functions of Shelterin Components in ALT Cells

Y Zhang, K Hou, J Tong, H Zhang, M Xiong… - International Journal of …, 2023 - mdpi.com
telomere-binding proteins to telomeres or elicit DDR, implying that TRF2 suffices to repress
the ATM kinase and C-NHEJ pathways at telomeres… HR in Caenorhabditis elegans telomere […

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends

N Bettin, E Querido, I Gialdini, GP Grupelli, E Goretti… - Science …, 2024 - science.org
… -mediated mRNA decay (NMD) pathway (1) and members of … telomeres, while expression
of a mutant form of the telomerictelomerase in budding yeast, it can repress telomerase in …