Emerging therapeutic strategies for Parkinson's disease and future prospects: A 2021 update

NA Gouda, A Elkamhawy, J Cho - Biomedicines, 2022 - mdpi.com
… In this review, we briefly introduce current treatments and pathophysiology of PD. In
addition, we address the novel innovative therapeutic targets for PD therapy, including α-synuclein, …

Natural phytochemicals as novel therapeutic strategies to prevent and treat Parkinson's disease: current knowledge and future perspectives

R Balakrishnan, S Azam, DY Cho… - … and Cellular …, 2021 - Wiley Online Library
… boost the cellular antioxidant defense system and related molecules, … cell survival systems
[26–31], suggesting that these phytochemicals have therapeutic potential for the treatment of …

Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives

D Przewodowska, W Marzec… - Frontiers in Molecular …, 2021 - frontiersin.org
disease-modifying treatments is of great scientific interest for many groups. Thus, this review
summarizes recent progress and perspectives regarding novel therapies for APS (Figure 1). …

A comprehensive approach to Parkinson's disease: addressing its molecular, clinical, and therapeutic aspects

M Muleiro Alvarez, G Cano-Herrera… - … Journal of Molecular …, 2024 - mdpi.com
… This article aims to address the general aspects of PD and to … latest therapeutic advancements
and emerging treatments for … perspective of mitochondrial biology in Parkinson’s disease. …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - … and targeted therapy, 2023 - nature.com
… progressive disorder especially the increasing severity of treatment-resistant motor and
non-… the clinical features and diagnostic criteria of PD, summarized the molecular mechanisms …

Cellular and molecular pathophysiology in the progression of Parkinson's disease

V Zaman, DC Shields, R Shams, KP Drasites… - … brain disease, 2021 - Springer
… of the disease. Studies in animal models and human post-mortem tissue have identified distinct
cellular and molecular … between different glial cell types and various molecular pathways. …

Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review

M Rekatsina, A Paladini, A Piroli, P Zis, JV Pergolizzi… - … in therapy, 2020 - Springer
… in the pathogenesis of Parkinson’s disease. As … of Parkinson’s disease [16]. A number of
potential contributors to OS have been implicated in the disease process of Parkinson’s disease

The future of stem cell therapies for Parkinson disease

M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
… fetal cell-derived therapiesParkinson disease features that dopamine cell replacement
based on generating neurons from human pluripotent stem cells could effectively treat in the future

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
… arsenal for the further development of efficient, nontoxic, and non-invasive therapeutic
protocols for disease-modifying therapy that tackles disease onset and progression in the future. …

Levodopa therapy for Parkinson's disease: history, current status and perspectives

H Bogetofte, A Alamyar, M Blaabjerg… - CNS & Neurological …, 2020 - ingentaconnect.com
… use in the treatment of PD. We furthermore review current evidence of the L-dopa-… side
effects and perspectives of L-dopa treatment in PD compared to other established treatments