Capturing the environment of the Clostridioides difficile infection cycle

MK Schnizlein, VB Young - Nature Reviews Gastroenterology & …, 2022 - nature.com
difficile (formerly Clostridium difficile) infection is a … of infection dynamics such as by protecting
against subsequent exposure or shifting immune responses due to multiple sources of C. …

Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers

…, F Rosa, F Manca, G Pignataro, C Zanza… - International Journal of …, 2022 - mdpi.com
Clostridium difficile infection is an emblematic example of how a normal and physiological
composition of the human microbiome can play a very important role in immune defense …

Host immunity and immunization strategies for Clostridioides difficile infection

F Naz, WA Petri - Clinical Microbiology Reviews, 2023 - Am Soc Microbiol
immune responses, adaptive immune responses, and the link between innate and adaptive
immune responses of the host against CDI… The other major determinants of CDI, such as C. …

Invisible steps for a global endemy: molecular strategies adopted by Clostridioides difficile

K Fettucciari, P Marconi… - Therapeutic …, 2021 - journals.sagepub.com
… and can increase the survival of senescent cells; fourth, Tcds block mobility and induce
apoptosis in immune cells recruited at the infection site; and finally, after remission from primary …

[HTML][HTML] Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases

G Bassotti, A Fruganti, F Stracci, P Marconi… - World Journal of …, 2023 - ncbi.nlm.nih.gov
difficile infection, such as the inflammatory state, and abnormalities of the microbiome and
of the immune system; (2) for the enhancement of the cytotoxic activity of TcdB +Cks; and (3) …

Systems approaches for the clinical diagnosis of Clostridioides difficile infection

Q Wu, TC Savidge - Translational Research, 2020 - Elsevier
… In this review, we consider how integration of microbiome and host immune systems biology
data may aid in the clinical diagnosis of CDI when validated against gold standard testing …

Clostridioides difficile Infection: The Challenge, Tests, and Guidelines

DM Lyerly, JH Boone, RJ Carman… - ACS Infectious …, 2020 - ACS Publications
C. difficile infection (CDI) is the primary hospital-acquired infection in North America and
Europe, and it now is a global disease. Even with newer laboratory tests, there still is confusion …

Host Immune Markers Distinguish Clostridioides difficile Infection From Asymptomatic Carriage and Non–C. difficile Diarrhea

…, CA Cuddemi, K Daugherty, C Barrett… - Clinical Infectious …, 2020 - academic.oup.com
… —thus addressing an important clinical diagnostic conundrum. … susceptibility of an at risk
patient to develop or redevelop Clostridium difficile infection.” NRP has acted as a paid speaker …

Clostridioides difficile: current overview and future perspectives

J Giles, A Roberts - Advances in Protein Chemistry and Structural Biology, 2022 - Elsevier
difficile, previously referred to as Clostridium difficile (C. … difficile infection typically occurs in
adults after the use of … is likely attributed to a weaker immune system and the presence of co-…

Microbiota in organ transplantation: An immunological and therapeutic conundrum?

KJ Dery, K Kadono, H Hirao, A Górski… - … immunology, 2020 - Elsevier
… promising results in the treatment of recurrent Clostridium difficile infection [36]. To date, …
presenting with recurrent Clostridium difficile (rCDI) with subsequent loss of C. difficile and its …