Plasma-signature-model for end-stage liver disease score to predict survival in severe alcoholic hepatitis

N Fujiwara, E Trépo, I Raman, QZ Li, D Degré… - Clinical …, 2022 - Elsevier
… their hepatic molecular dysregulation status and combining it … with that of gene
expression–based prediction. By using … score, ps-MELD was defined as follows: ps-MELD score = …

Classification and survival prediction in early‐stage cirrhosis by gene expression profiling

Q Wang, X Li, Y Chen, J Gong, B Hu - Journal of Viral Hepatitis, 2023 - Wiley Online Library
… to the end-stage liver complications such as gastrointestinal bleeding, liver failure and …
were employed to build the PPI network, and a combined score ≥0.4 was used as the threshold …

Molecular signature predictive of long-term liver fibrosis progression to inform antifibrotic drug development

T Qian, N Fujiwara, B Koneru, A Ono, N Kubota… - Gastroenterology, 2022 - Elsevier
predicts adverse outcomes in patients with advanced liver … of the CES and differential gene
expression were tested by … We identified 4 candidate combinations based on EGCG as a …

[HTML][HTML] A robust gene expression signature for NASH in liver expression data

Y Hasin-Brumshtein, S Sakaram, P Khatri, YD He… - Scientific Reports, 2022 - nature.com
… -Alcoholic Fatty Liver Disease (NAFLD) is a progressive liver disease … We showed that gene
expression data combined with … liver fibrosis and may lead to cirrhosis and end-stage liver

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

O Govaere, S Cockell, D Tiniakos, R Queen… - Science translational …, 2020 - science.org
… may progress to cirrhosis and, ultimately, end-stage liver disease (2). … of NAFLD, we identified
and validated gene expression … This combined model to predict fibrosis had a significantly …

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

N Fujiwara, N Kubota, E Crouchet, B Koneru… - Science translational …, 2022 - science.org
… a combination of these HCC risk predictive signatures as an … these signatures reflect cause
or consequence of disease … PLS-NAFLD is the first gene expression signature to predict

[HTML][HTML] A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

N Fujiwara, M Kobayashi, AJ Fobar, A Hoshida… - Med, 2021 - cell.com
liver secretome signature (PLSec). PLSec predicts long-term HCC risk in patients with
advanced liver … organ of interest, called translation of gene expression to SECretome (TexSEC) (…

[HTML][HTML] An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease

TJ Kendall, M Jimenez-Ramos, F Turner… - Nature medicine, 2023 - nature.com
… a 15-gene transcriptional risk score to predict future hepatic … drugs and therapeutic
combinations to mitigate adverse … explants for clinically end-stage NAFLD cirrhosis. A clinical …

MELD 3.0: the model for end-stage liver disease updated for the modern era

WR Kim, A Mannalithara, JK Heimbach, PS Kamath… - Gastroenterology, 2021 - Elsevier
… Although the latter 2 variables are already in the mix, the inclusion of race could be …
constructed a multivariable Cox model predicting mortality up to 90 days. Considered in the …

Gene signature‐MELD score and alcohol relapse determine long‐term prognosis of patients with severe alcoholic hepatitis

P Deltenre, E Trépo, N Fujiwara, N Goossens… - Liver …, 2020 - Wiley Online Library
… In this study, gs-model for end stage liver disease score and … or the combination of the Lille
and the MELD scores of being … this score outperformed other clinical models for prediction of …