… the role of Aβ and BACE1 in physiological processes and key … also decrease acetylated H3
to reduce BACE1 transcripts (21). On … High BACE1 enzymatic activity was found in human AD …

… of BACE1 inhibitors on its opposing enzymatic functions, ie, … , and actin (control), or cell
media for secreted sAPPβ. B–E, … of BACE1, APP, sAPPβ, or mature APP as a function of BACE1 …

… an optimal environment for BACE1 enzymatic activity and APP cleavage 22. While … that
AP‐2 affects APP processing and Aβ production in neurons via the regulation of BACE1 …

… as a repressor of APP, BACE1, and the two primary forms of Aβ (… Each reaction contained
1.3 μl of reverse transcription … effects against abnormal APP processing and Aβ-toxicity in AD […

… The interaction network of BACE1 and its phosphorylation enzyme CSNK1D functionally …
role in mediating Aβ induced upregulation of BACE1 activity and APP processing (Shen et al…

… Nav1.6 reduces the transcription level of β-site APP-cleaving enzyme 1 (BACE1), which is
… .6-enhancing BACE1 transcription depends on Aβ oligomer-mediated pathological process. …

… , β-secretase (BACE1) is the first and rate-limiting enzyme. Its … the BACE1 transcription
and protein levels, resulting in Aβ … and subsequently inducing the Aβ generation in both 5×FAD …

… on the role of Aβ in AD pathogenesis, the relationship between BACE1 and AβO, and the …
as an enzyme in a key rate-limiting processing step of Aβ generation, BACE1 also regulates …

… and expression of APP, BACE1, and Sp1 transcription factor … by an increase in BACE1
enzymatic activity, Aβ, and receptor … Aβ aggregation by increasing the levels of BACE1, APP, and …

… of Aβ generation due to their optimal acidic pH for BACE1 … Transcript levels were normalized
to those of IPO8, identified by … Rab35 regulates APP processing at the subcellular level, we …