Fear extinction learning and anandamide: an fMRI study in healthy humans

J Spohrs, M Ulrich, G Grön, M Prost, PL Plener… - Translational …, 2021 - nature.com
… Based on a translational approach, we set up a fear conditioning-extinction paradigm to …
studies in rodents suggesting a core role of AEA in extinction learning. After identifying central …

The endocannabinoid system in the amygdala and modulation of fear

O Gunduz-Cinar - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Convergent benefits of neuroanatomical homology between … In this review, the neurocircuitry
contributing to fear extinction … endocannabinoid anandamide (AEA) modulates extinction

A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

O Gunduz-Cinar, LI Castillo, M Xia, E Van Leer… - Neuron, 2023 - cell.com
fear extinction and inform efforts to target the eCB system as a therapeutic approach in …
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction

[HTML][HTML] Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: a randomized …

LM Mayo, A Asratian, J Lindé, M Morena, R Haataja… - Biological …, 2020 - Elsevier
… the consolidation of fear extinction memories and protects against … Initial evidence that these
findings may have a translationalConverging evidence from preclinical models and human …

Exercise-induced increases in Anandamide and BDNF during extinction consolidation contribute to reduced threat following reinstatement: Preliminary evidence from …

KM Crombie, A Sartin-Tarm, K Sellnow… - …, 2021 - Elsevier
… In order to begin to examine the translational relevance of these findings, we recently …
aerobic exercise performed shortly after fear extinction training improves the consolidation of fear

Neuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: Synaptic transmission and …

S Battaglia, C Di Fazio, CM Vicario… - International Journal of …, 2023 - mdpi.com
evidence supporting the hypothesis that NMDA antagonists may have an excitatory role in
human fear extinction … and endocannabinoid anandamide levels in extinction learning will be …

Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder

A Vimalanathan, DC Gidyk, M Diwan, FV Gouveia… - …, 2020 - Elsevier
… Rats undergoing fear conditioning/extinction and fear recall sessions were initially …
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, …

[HTML][HTML] Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1

M Ten-Blanco, Á Flores, I Pereda-Pérez… - Biomedicine & …, 2022 - Elsevier
… In this study, we investigated the participation of the ECS in the fear extinction deficits induced
by orexin-A. Understanding the neurobiological mechanisms involved in these effects is …

The role of the cannabinoid system in fear memory and extinction in male and female mice

I Mizuno, S Matsuda, S Tohyama, A Mizutani - Psychoneuroendocrinology, 2022 - Elsevier
… This decrease is called fear extinction, and it is noted that fear extinction does not …
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, …

[HTML][HTML] The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

KM Crombie, AA Privratsky, CM Schomaker… - NeuroImage: Clinical, 2022 - Elsevier
… Elevations in one of the major endocannabinoids (anandamide) either via inhibition of the
primary … Early seminal studies examining the role of the eCB system in fear extinction learning …