Non-nucleoside reverse transcriptase inhibitors (NNRTIs): A brief overview of clinically approved drugs and combination regimens
The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-
1 reverse transcriptase and are classified into generations depending on their discovery and
resistance profiles. The NNRTIs are used in combination regimens with antiretroviral agents
that target two or more enzymes in the viral life cycle. The combination regimens usually
include a backbone of two nucleoside or nucleotide reverse transcriptase inhibitors and a
third core agent among the NNRTIs or protease inhibitors. The combination regimens are …
1 reverse transcriptase and are classified into generations depending on their discovery and
resistance profiles. The NNRTIs are used in combination regimens with antiretroviral agents
that target two or more enzymes in the viral life cycle. The combination regimens usually
include a backbone of two nucleoside or nucleotide reverse transcriptase inhibitors and a
third core agent among the NNRTIs or protease inhibitors. The combination regimens are …
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