… homologous repair deficiency (HRD) markers determine … To identify patients who could
potentially benefit from PARP … between the HRD and HR-proficient populations (data not shown). …

… cancers with a defect in HR DNA repair, regardless of the … indirectly as a possible clinical
marker of tumor HRD. … debate in metastatic HRD-high BRCA proficient patients, also regarding …

… issue associated with a much higher risk of death. The … breast cancer subtype as to minimize
treatment morbidity and mortality. Identifying early-stage breast cancer patients at high-risk …

… The aim of our study was to identify new potential prognostic markers for TNBC and … -1
(PARP1) is a member of the PARP family, which has 17 members total and plays a role in …

Frontiers | Risk stratification based on DNA damage-repair-related signature reflects the
microenvironmental feature, metabolic status and therapeutic response of breast cancer Skip to …

… Visual summary of types of genetic markers of homologous recombination DNA repair …
HR-proficient [34]. This HRD score was evaluated in trials of neoadjuvant chemotherapy in breast …

… DNA damage is one of the main drivers of cancer promotion … repair systems are involved
in the restoration of damage. … accurate double-strand DNA damage repair (DDR) mechanism […

… used as a marker of DNA damage and repair. A prior … detection of γ-H2AX expression,
assessment of H2AX mRNA expression is less subjective and cost effective with less proficiency …

… within DNA repair genes, or with a strong family history of breast … that are HR-proficient
versus -deficient tumours [25,26]. … EGFR as a prognostic marker in familial breast tumours, or the …

… are high penetrance genes associated with an increased risk … We believe that older people
with no personal cancer history … We identified 667 single nucleotide variants (SNVs) and …