… DNA damage repair (DDR) comprises the detection and correction of alterations in the
chemical structure of DNA. The … hinder the clinical potential application of these ICI markers. For …

… While large-scale screening for HRD using genomic markers is … tissue slides and identifying
related morphological phenotypes, … Homologous recombination DNA repair deficiency and …

… We review the predictive role of a range of DNA repair genes, … targeted the DNA damage
response in BRCA1/2-mutated breast and … recombination–proficient (HRP) and HRD cancers. …

… BRCA1/2 mutations across breast, ovarian and pancreatic cancer [… Loss of HR proficiency
is the clinical indication for PARPi … profiles of 236 DNA damage repair genes were generated …

… by aggressive behavior, high risk of distant recurrence, and … methods to score the competency
of the HR pathway. Three … DNA mismatch repair mechanism (deficient mismatch repair; …

… DNA damage is repaired by multiple interconnected … observed to be a surrogate marker of
HR proficiency and in itself a … sites of DSBs with breast cancer 2 (BRCA2) can be visualized in …

… in these genes compared to breast and ovarian cancer [43]. … as an intermediate or high
risk of recurrence, metastasize … -proficient (pMMR), and the enzymes of mismatch repair are …

… earlier than the MMR-proficient ones. These differences in … in all related family members,
providing the opportunity for … carriers are at risk of different cancer types (ie breast, ovarian…

… DNA damage caused by high estrogen levels cause … (GSA) of the core markers expressed
in cluster 4 points to … assist others in attaining greater proficiency. Training activities may …

… Proficiency Score was calculated to assess DNA repair efficiency. … Molecular markers
identified on fine-needle aspiration of … The RPS has been used as a biomarker in lung and breast …