[HTML][HTML] Diversity of the reaction mechanisms of SAM-dependent enzymes

Q Sun, M Huang, Y Wei - Acta Pharmaceutica Sinica B, 2021 - Elsevier
… crucial role in epigenetic regulation of macromolecules and … DNA and protein MTases whose
abnormal activity is thought to … Further understanding of the molecular mechanism of these …

[HTML][HTML] Structure and catalytic mechanism of radical SAM methylases

TQ Nguyen, Y Nicolet - Life, 2022 - mdpi.com
… Conventional SAM-dependent methyltransferases catalyze … emphasizes the importance
of understanding their function, … coordinating the unique iron would play a “switching” role to …

[HTML][HTML] Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

X Guo, A Söderholm, S Kanchugal P, GV Isaksen… - Elife, 2021 - elifesciences.org
… For this reason, the exact size of the original open reading frame was unknown, but an N-…
, the proteins were highly toxic and the tightly regulated, arabinose-inducible BL21-AI cells had …

Substrate-controlled catalysis in the ether cross-link-forming radical SAM enzymes

S Ma, W Xi, S Wang, H Chen, S Guo, T Mo… - Journal of the …, 2023 - ACS Publications
… co-occurs with a small open reading frame (sORF) with one or … catalytic outcome of daropeptide
maturase can be regulated … , we have shown that the unusual biochemistry is not limited …

Cascading proton transfers are a hallmark of the catalytic mechanism of SAMdependent methyltransferases

LN Zhao, P Kaldis - FEBS letters, 2020 - Wiley Online Library
understandingenzymes from the same family with uncharacterized activity have tyrosines
at the active site. Meanwhile, our study provides a unique insight into the reaction mechanism

Structure-based insights into recognition and regulation of SAM-sensing riboswitches

L Zheng, Q Song, X Xu, X Shen, C Li, H Li… - Science China Life …, 2023 - Springer
… core scaffold to support their unique ligand-specific binding … recognition and gene
regulation mechanism of these SAM-… achieve RNA methylation (SAM-dependent methyltransferase …

Radical SAM enzymes involved in tetrapyrrole biosynthesis and insertion

G Layer, M Jahn, J Moser, D Jahn - ACS bio & med Chem Au, 2022 - ACS Publications
… chlorophylls is based on an unusual six-electron oxidative cyclization … Also, the understanding
of the details of CgdH catalysis … For all of these reasons, the catalytic mechanisms of AhbD …

Structural Features and Substrate Engagement in Peptide-Modifying Radical SAM Enzymes

LE Cheek, W Zhu - Archives of Biochemistry and Biophysics, 2024 - Elsevier
… the progress in understanding the activity regulation through … a cationic intermediate,
SAM-dependent methylation, or metal… 5d), which is highly unusual in rSAM enzymes. Replacing …

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

GV Isaksen, X Guo, A Söderholm, S Kanchugal P… - 2021 - munin.uit.no
… For this reason, the exact size of the original open reading … highly toxic and the tightly regulated,
arabinose-inducible BL21-… The catalytic mechanism of Svi3-3 was investigated with DFT …

[HTML][HTML] Structural similarities between SAM and ATP recognition motifs and detection of ATP binding in a SAM binding DNA methyltransferase

S Sankar, P Preeti, K Ravikumar, A Kumar… - Current Research in …, 2023 - Elsevier
… Besides methylation, SAM dependent methyltransferase can … that enzymes utilize. In cellular
metabolism, a number of … aims to decipher the structural determinants of SAM recognition. …