… and spine numbers of cortical neurons in vitro. Using old mice… accompanied by increased
prevalence of cognitive decline … we hypothesized that facilitating the action of GABA at the α 5 -…

… in neural distinctiveness can account for a number of … neurons in young monkeys respond
less selectively, like the … We also found age-related neural dedifferentiation in older compared …

… of cognitive functions—usually accompanied or preceded by a deterioration of emotional …
GABA in age-related cognitive decline. Several previous articles have thoroughly reviewed …

… In summary, aging is accompanied in the CN by decreases in … of a significant age-related
neuronal loss. Thus, aging is not … , the number of GABA-immunoreactive neurons was reduced …

… and proteomic degradation. We show an age-dependent … mechanism in the age-related
decline in cognitive abilities and … individuals having a higher proportion of synaptic GluN2B-…

… variability, we examined whether reduced brain signal … then decomposed using singular
value decomposition (SVD). This … in brain regions showing age-related reductions in SD BOLD , …

… age-related behavioral impairments, and that number is only … ; it is typically accompanied
by a decrease in physical and … single neurons and that age-related declines in GABA levels …

… Here, we hypothesized that targeting the α5-GABA-A receptors … lifespan is accompanied by
normal cognitive decline and … aging induces neuronal loss contributing to cognitive decline. …

… and functional alterations accompanying senescence. We … We find that manipulation of
inhibitory GABA signaling can … in neuronal signaling and activity drive age- related decline in …

… this review will detail how age-related changes in these circuits … low doses of GABA (0–10
nA) failed to alter IC neuronal … activity followed by or accompanied with high frequency bursts …