… meta-analysis of data from multiple GWAS studies 41,42,43 . … of large cohorts, human genetics
has deployed increasingly … mapping the genetic factors that underlie traits and diseases. …

… analyses, both in the discovery of genetic variants for sex hormone traits and in the analyses
of downstream traits. The apparently sex-divergent effects of testosterone on T2D were …

… Focusing on rarer PTVs (MAF < 1%), we observed that 95% of genes had at least one
heterozygous PTV carrier, 42% had at least one compound heterozygous or homozygous/…

… Understanding the genetic factors driving this variability in ageing between … in human ageing
is limited and conventional observational studies are often distorted by confounding factors …

… To assess the shared genetic effects between sarcomere-positive and sarcomere-negative
HCM at individual loci, pairwise GWAS calculated the probability that a variant located within …

… four broad factors that index shared genetic liability within and … We then evaluate the utility
of these factors using a multistep … genetic enrichment of variance in psychiatric genetic factors …

… microbiome trait loci (mbTL) mapping to identify genetic loci … trait loci, or mbQTLs) or presence
(microbiome binary trait loci… interpretation of GWAS findings through gene-set enrichment …

… the nomination of disease genes and drug candidates by incorporating gene and protein
expression data and providing insight into the underlying biology of human diseases and traits. …

… 52 framework for identification of regulatory and tissue enrichments. Because this analysis
uses the complete GWAS dataset of a trait, pooling of data from multiple traits, as done above, …

… -trait colocalization … traits and diseases that share common genetic etiology and mechanisms.
To investigate whether changes in gene expression and protein abundance influence trait …