Validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
ABSTRACT Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and
environmental risk factors that disproportionately afflicts communities of color. Leveraging
existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS)
have shown promise to complement established clinical risk factors and intervention
paradigms, and improve early diagnosis and prevention of T2D. However, to date, T2D PRS
have been most widely developed and validated in individuals of European descent …
environmental risk factors that disproportionately afflicts communities of color. Leveraging
existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS)
have shown promise to complement established clinical risk factors and intervention
paradigms, and improve early diagnosis and prevention of T2D. However, to date, T2D PRS
have been most widely developed and validated in individuals of European descent …
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color.
Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk
scores (PRS) have shown promise to complement established clinical risk factors and
intervention paradigms, and improve early diagnosis and prevention of T2D. However, to
date, T2D PRS have been most widely developed and validated in individuals of European …
and environmental risk factors that disproportionately afflicts communities of color.
Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk
scores (PRS) have shown promise to complement established clinical risk factors and
intervention paradigms, and improve early diagnosis and prevention of T2D. However, to
date, T2D PRS have been most widely developed and validated in individuals of European …
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