Cytokines: from clinical significance to quantification

C Liu, D Chu, K Kalantar‐Zadeh, J George… - Advanced …, 2021 - Wiley Online Library
… However, cytokine therapy also suffers from a number of … cells then further release several
proinflammatory cytokines … -expressed Jurkat cells were utilized to evaluate the sensitivity and …

Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Inflammatory cytokines modulate phenotype and function of all myocardial cells, … In
addition to their role in adverse cardiac remodeling, some inflammatory cytokines may also exert …

Harnessing cytokines and chemokines for cancer therapy

DJ Propper, FR Balkwill - Nature reviews Clinical oncology, 2022 - nature.com
… thyroid cells induces a network of pro-inflammatory cytokines … , and can be directly cytotoxic
or cytostatic to malignant cells. … and their signalling pathways had reduced susceptibility to …

Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy

T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
… Equipped with the accumulating understanding of the antitumor functions of IFNs, some
type I and type II IFNs have already been directly or indirectly applied to the development of …

… of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
… of numerous types of pro-inflammatory cytokines and … 2 exhibits higher vulnerability to type
I IFN compared to SARS… The soluble ACE2 may be directly contributed to the inflammatory

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

SA Ihim, SD Abubakar, Z Zian, T Sasaki… - Frontiers in …, 2022 - frontiersin.org
… increased susceptibility to infection and impaired NK cellinflammatory cytokines in
comparison to those from wild type … of combination drug therapies that specifically focus on IL-18 …

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

OJ McElvaney, GF Curley, S Rose-John… - The Lancet …, 2021 - thelancet.com
… of direct cytokine inhibition does not prevent other cytokines … change course in patients more
prone to sudden fluctuation (… outpatients receiving the therapy for rheumatological disease …

Role of inflammatory cytokines, growth factors and adipokines in adipogenesis and insulin resistance

L Al-Mansoori, H Al-Jaber, MS Prince, MA Elrayess - Inflammation, 2022 - Springer
… the development of novel therapeutic strategies for individuals at … IL-15 is another pro-inflammatory
cytokine that directly reduces … and modulating insulin sensitivity. These include IL-1 …

Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… more prone to severe complications of COVID-19 compared to … of the disease is directly
proportional to the concentration of … therapeutic agents to control the pro-inflammatory cytokine

Interleukin‐31: The “itchy” cytokine in inflammation and therapy

A Datsi, M Steinhoff, F Ahmad, M Alam, J Buddenkotte - Allergy, 2021 - Wiley Online Library
… likely accounting for the higher “skin sensitivity” in AD … neural changes occur in direct
response to inflammatory signals. … stromal cells and produces various pro-inflammatory cytokines