… effect of the extract on pharmacokinetics of co-administered … reported that in healthy Chinese
subjects, silymarin (140 mg … significantly decreased the oral clearance (CL/F) of talinolol, a P…

… [21] and is bioavailable approximately 33% after oral administration [22]. It undergoes first
… , silymarin has been reported to significantly increase the plasma concentration of talinolol; …

… Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy
volunteers. Xenobiotica 2009; 39(9): 694-699. [139] Farkas D, Greenblatt DJ. …

… oral dose of GBE did not show any change in the pharmacokinetics of talinolol in 10 healthy…
administration of milk thistle as compared to placebo treatment, in human studies. AUC of …

… In this chapter additional protective effects of silymarin (SM) are described including amatoxin…
Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy …

… oral administration, suggesting a weak inhibitory effect of … milk thistle extract and silymarin
at certain doses dramatically altered the pharmacokinetic parameters of these drugs in healthy …

… and modified the pharmacokinetics and the therapeutic effect of 27 … It should be noted that
the beneficial health effects attributed to … All PCH were co-administered orally with drug in both …

… It can impact health and the effectiveness of treatments. … data about the milk thistle inhibitory
action on CYP enzymes … results in a decrease in oral pharmacokinetics of cyclosporine. In …

… For this purpose, pigs (n = 3) were orally administered SM at … in its pharmacokinetic profile
[37]. Of note, SM has shown to … any effect on healthy hearts, we can postulate that SM effects …

… In this work, an extensive database of talinolol pharmacokinetics was 12 established and …
Effect of continuous silymarin 507 administration on oral talinolol pharmacokinetics in healthy …