Effect of molnupiravir on biomarkers, respiratory interventions, and medical services in COVID-19: a randomized, placebo-controlled trial
MG Johnson, A Puenpatom, PA Moncada… - Annals of internal …, 2022 - acpjournals.org
MG Johnson, A Puenpatom, PA Moncada, L Burgess, ER Duke, N Ohmagari, T Wolf…
Annals of internal medicine, 2022•acpjournals.orgBackground: In the MOVe-OUT trial, molnupiravir showed a clinically meaningful reduction
in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk
factors for progression to severe disease. Objective: To identify other potential clinical
benefits of molnupiravir versus placebo. Design: Secondary analysis of the randomized,
double-blind, placebo-controlled phase 3 component of MOVe-OUT.(ClinicalTrials. gov:
NCT04575597) Setting: 107 sites globally. Participants: 1433 nonhospitalized adults aged …
in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk
factors for progression to severe disease. Objective: To identify other potential clinical
benefits of molnupiravir versus placebo. Design: Secondary analysis of the randomized,
double-blind, placebo-controlled phase 3 component of MOVe-OUT.(ClinicalTrials. gov:
NCT04575597) Setting: 107 sites globally. Participants: 1433 nonhospitalized adults aged …
Background
In the MOVe-OUT trial, molnupiravir showed a clinically meaningful reduction in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk factors for progression to severe disease.
Objective
To identify other potential clinical benefits of molnupiravir versus placebo.
Design
Secondary analysis of the randomized, double-blind, placebo-controlled phase 3 component of MOVe-OUT. (ClinicalTrials.gov: NCT04575597)
Setting
107 sites globally.
Participants
1433 nonhospitalized adults aged 18 years or older with mild to moderate COVID-19.
Intervention
Molnupiravir, 800 mg, or placebo every 12 hours for 5 days.
Measurements
Changes from baseline in C-reactive protein (CRP) concentration and oxygen saturation (Spo 2), need for respiratory interventions (including invasive mechanical ventilation), and need for medical services in all randomly assigned participants through day 29, and need for respiratory interventions and time to discharge in the subgroup of participants who were hospitalized after randomization.
Results
Participants receiving molnupiravir showed faster normalization of CRP and Spo 2, with improvements observed on day 3 of therapy, compared with placebo. Molnupiravir-treated participants had a decreased need for respiratory interventions versus placebo-treated participants (relative risk reduction [RRR], 34.3% [95% CI, 4.3% to 54.9%]), with similar findings in participants who were hospitalized after randomization (RRR, 21.3% [CI, 0.2% to 38.0%]). Hospitalized participants who received molnupiravir were discharged a median of 3 days before those who received placebo. Acute care visits (7.2% vs. 10.6%; RRR, 32.1% [CI, 4.4% to 51.7%]) and COVID-19–related acute care visits (6.6% vs. 10.0%; RRR, 33.8% [CI, 5.6% to 53.6%]) were less frequent in molnupiravir- versus placebo-treated participants.
Limitations
Some analyses were performed post hoc. Longer-term benefits of molnupiravir therapy were not evaluated. Participants were not immunized against SARS-CoV-2.
Conclusion
The findings suggest there are additional important clinical benefits of molnupiravir beyond reduction in hospitalization or death.
Primary Funding Source
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.
acpjournals.org
以上显示的是最相近的搜索结果。 查看全部搜索结果