Genetic variation of glycophorins and infectious disease

EJ Hollox, S Louzada - Immunogenetics, 2023 - Springer
gene conversion events from sequence read mis-mapping. … A functional study suggested
that an allele at GYPC encoding … a major agent of natural selection in humans who live where …

Genome structural variation in human evolution

EJ Hollox, LW Zuccherato, S Tucci - Trends in Genetics, 2022 - cell.com
evolving neutrally, with selection having no effect on the allele frequency. Early studies on
SVs in humans … allowing extensive gain of copy number of olfactory receptor genes encoding

Identifying adaptive alleles in the human genome: from selection mapping to functional validation

EA Werren, O Garcia, AW Bigham - Human genetics, 2021 - Springer
… acknowledge the impact of this major Eurocentric bias in the current map of natural selection
in humans, … for population geneticists, human geneticists, and molecular anthropologists. …

Host genetics and infectious disease: new tools, insights and translational opportunities

AJ Kwok, A Mentzer, JC Knight - Nature Reviews Genetics, 2021 - nature.com
… locus neighbouring glycophorin genes (encoding erythrocyte … translational impact,
polymorphisms in the gene encodingnatural selection. For example, for cholera, targets of …

Genomic structural variation: A complex but important driver of human evolution

DC Soto, JM Uribe‐Salazar, CJ Shew… - American Journal of …, 2023 - Wiley Online Library
… played a role in natural selection, and (3) the role of gene duplications in … IGC Interlocus
gene conversion … CNVs of coding regions can directly impact gene dosage, while SVs of …

Three signatures of adaptive polymorphism exemplified by malaria-associated genes

JA Tennessen, MT Duraisingh - … Biology and Evolution, 2021 - academic.oup.com
selection in the human genome center on genes that impact … top 50 candidate genes by
ranking all protein-coding genes … other, a signal of natural selection sweeping away variation in …

[HTML][HTML] How genetics might explain the unusual link between malaria and COVID-19

M Rusmini, P Uva, A Amoroso, M Tolomeo… - Frontiers in …, 2021 - frontiersin.org
… therefore natural selection has promoted the genetic variants … of both glycophorin B and
FREM3, and how this effect can … expression of PIR, a gene encoding the enzyme quercetin 2,3-…

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

MT Naung, E Martin, J Munro, S Mehra… - PLoS Computational …, 2022 - journals.plos.org
… We analysed the genes encoding 23 leading and novel … Measures of natural selection were
then mapped to 3D protein … as it binds to human receptor glycophorin A. During dimerization, …

[HTML][HTML] Host-malaria parasite interactions and impacts on mutual evolution

X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
… , Pf EBA175 recognizes glycophorin A, and invasion of human erythrocytes by P. …
consequences of these host-parasite interactions is increased genetic diversity at genes encoding

Structural variation of the malaria-associated human glycophorin ABE region

S Louzada, W Algady, E Weyell, LW Zuccherato… - BMC genomics, 2020 - Springer
gene dosage effect. It is known that DUP4 results in a GYPB-GYPA fusion gene that codes
… , suggesting a history of gene conversion events between the glycophorin repeat regions (…