… the metabolome and its dynamic nature, we highlighted age-associated metabolic changes
… , proteomics, and metabolomics may provide novel insight into the aging process. In this …

… respiration and might indicate changes in the musculature (55)… insights into cell- and
tissue-specific metabolic changes in … age-associated metabolites presumably provide insight into …

… It was proposed that high NAD + levels support senescence-related metabolic changes,
and also promote AMPK and NF-κB signaling pathways that activate the expression of …

… Aging is a process associated with organ function decline and metabolic changes, … [ 31 ]
Altered blood metabolites in the process of human aging can reveal gerontological markers and …

… of it making improvements in aging, and pharmacogenomics. … A current challenge is to
determine the metabolic changes … , have offered some insight into the molecular underpinnings of …

… Various metabolic pathways in cardiomyocytes and noncardiomyocytes determine cellular
senescence in the aging heart. Metabolic alteration is a common process throughout cardiac …

… metabolomics study of aging brain tissue to date. In the present paper, we first provide an
overview of the extensive metabolic changes … novel insights into metabolic alterations in brain …

… during prolonged fasting was performed to gain insights into its health effects [54]. Therefore…
to metabolic changes. Increased purines and pyrimidines may support anabolic metabolism …

… By this approach, we have reported 14 age-related compounds and 15 markers for frailty, a
… to adapt to metabolic changes. Consistently, whole blood metabolomics identified purines …

… aging mechanisms has since emerged that identifies dysregulated metabolism as one of
many hallmarks of aging … patterns, and genetic or metabolomic signatures that clearly underlie …