Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
age predictors utilising DNAm have been developed. These DNAm age predictors (more
commonly known as epigenetic … that have tractable changes with age. The majority of these …

Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging

A Li, Z Koch, T Ideker - Journal of Internal Medicine, 2022 - Wiley Online Library
… Here, we outline emerging areas of epigenetic aging research that prioritize biological …
progress in epigenetic clocks, which are beginning to predict not only chronological age but aging …

[HTML][HTML] Epigenetic age prediction in semen–marker selection and model development

A Pisarek, E Pośpiech, A Heidegger, C Xavier… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
age estimation. Although semen samples are often used in forensic DNA analysis, previous
epigenetic age prediction … DMSs moderately correlated with age. Validation of the ten most …

[HTML][HTML] New targeted approaches for epigenetic age predictions

Y Han, J Franzen, T Stiehl, M Gobs, CC Kuo, M Nikolić… - BMC biology, 2020 - Springer
… levels with age at … epigenetic age predictions based on the binary sequel of methylated
and non-methylated sites in individual reads, which reflects heterogeneity in epigenetic

DNA methylation-based age clocks: From age prediction to age reversion

R Noroozi, S Ghafouri-Fard, A Pisarek… - Ageing Research …, 2021 - Elsevier
… potential of estimated epigenetic age acceleration regarding … the revealed age-related
epigenetic changes, the recent age-… epigenetic age estimator (epigenetic age clock), epigenetic

Profiling epigenetic age in single cells

A Trapp, C Kerepesi, VN Gladyshev - Nature Aging, 2021 - nature.com
… We computed epigenetic age predictions in these MuSCs using three training models,
including muscle, blood and multi-tissue datasets. The muscle and multi-tissue clocks showed a …

GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality

C McCrory, G Fiorito, B Hernandez… - The Journals of …, 2021 - academic.oup.com
… clocks for clinical medicine by examining the utility of 4 epigenetic AA indices—HorvathAA, …
as markers of age-related decline. We also examine the utility of epigenetic AA for predicting …

[HTML][HTML] Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones

A Woźniak, A Heidegger, D Piniewska-Róg… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… Our study aimed to select a universal set of DMSs for epigenetic age prediction in various
somatic tissues, but since the pattern of DNA methylation change differed in various cell types …

[HTML][HTML] Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

CP Verschoor, DTS Lin, MS Kobor, O Mian, J Ma… - … epigenetics, 2021 - Springer
predict this and other important outcomes could be beneficial. … epigenetic clock delta age
estimate with frailty at baseline in separate models, adjusting for age and sex (model 1), or age, …

Epigenetic clock: A promising biomarker and practical tool in aging

R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
… Correlations of epigenetic age with morbidity, mortality and other factors suggest the potential
of epigenetic clocks for risk prediction and identification in the context of aging. In particular…