Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

CP Verschoor, DTS Lin, MS Kobor, O Mian, J Ma… - … epigenetics, 2021 - Springer
predict this and other important outcomes could be beneficial. … epigenetic clock delta age
estimate with frailty at baseline in separate models, adjusting for age and sex (model 1), or age, …

Epigenetic clock: A promising biomarker and practical tool in aging

R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
… Correlations of epigenetic age with morbidity, mortality and other factors suggest the potential
of epigenetic clocks for risk prediction and identification in the context of aging. In particular…

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

JD Faul, JK Kim, ME Levine… - Proceedings of the …, 2023 - National Acad Sciences
… of these epigenetic age acceleration measures with a composite measure of 22 primarily
blood-based clinical chemistry biomarkers that has been shown to predict multimorbidity in the …

Epigenetic age and the risk of incident atrial fibrillation

JD Roberts, E Vittinghoff, AT Lu, A Alonso, B Wang… - Circulation, 2021 - Am Heart Assoc
… effectively predict chronological age. … epigenetic age acceleration (EAA), which may reflect
accelerated biological aging. We sought to evaluate for associations between epigenetic age

A pan-tissue DNA-methylation epigenetic clock based on deep learning

LP de Lima Camillo, LR Lapierre, R Singh - npj Aging, 2022 - nature.com
… is a highly accurate and precise age predictor. Compared to ElasticNet, … epigenetic clock
with 71 CpG sites 2 . Then Horvath showed epigenetic clocks could also accurately predict age

Assessment of epigenetic clocks as biomarkers of aging in basic and population research

ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
epigenetic clocks routinely exhibit extremely high precision when it comes to age prediction,
… how well they predict chronological time, but rather how well they predict aging outcomes, …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Epigenetic clocks predict age or age-related phenotypes by combining the methylation
values of tens to hundreds of CpGs selected using machine learning approaches. The …

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood

EJ Hamlat, AA Prather, S Horvath… - Developmental …, 2021 - Wiley Online Library
… at menarche has yet to be assessed as a predictor of adult epigenetic age acceleration.
The research reported herein is thus the first to examine the associations between …

Association of cardiovascular health and epigenetic age acceleration

TD Pottinger, SS Khan, Y Zheng, W Zhang… - … epigenetics, 2021 - Springer
… CVH is known to predict longevity and freedom from … been aggregated into a composite
epigenetic age score, which is … as measured by DNA methylation markers in epigenetic age. …

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

RF Hillary, AJ Stevenson, DL McCartney… - … epigenetics, 2020 - Springer
… Genetic influences may contribute to differences in DNA methylation and the subsequent
estimation of epigenetic age or pace of ageing; therefore, it is possible that our findings may not …