K Raj, S Horvath - Experimental Biology and Medicine, 2020 - journals.sagepub.com
… The resulting “epigenetic clock” is a multivariate predictor of age (or alternatively mortality risk) based on a multivariate regression model that incorporates methylation values of …
… key epigeneticage changes and developed a novel rat epigenetic clock, which we show tracks age … By applying elastic net regression to the training set, we built an agepredictor that …
… of epigeneticage with time, where the epigeneticage increased at … predict that epigenetic ageing is faster during the active season and slower during hibernation. We test this prediction …
… The new clock is capable of predicting the epigeneticage of reduced representation bisulfite … (r ≥ 0.8) in ageprediction of test samples and were sensitive to age-related conditions and …
… Epigenetic modifications are closely linked with aging, but … in epigenetic aging, we explored sex-specific associations of 3 DNA methylation (DNAm)–based measures of epigeneticage …
… age of each sample and assessed for epigeneticage acceleration in the samples by regressing the estimated biological age on the individual’s chronological age… predict a variety of age…
S Kabacik, D Lowe, L Fransen, M Leonard, SL Ang… - Nature aging, 2022 - nature.com
… Epigenetic clocks are mathematically derived age estimators that are based on … change with age at specific CpGs in the genome. These clocks are widely used to measure the age of …
VM Vetter, CH Kalies, Y Sommerer… - The Journals of …, 2022 - academic.oup.com
… DNAmAA was able to predict impairment in the analyzed … epigeneticage estimates, DNA methylation age (DNAm age) and particularly its deviation from chronological age, DNAm age …
B Mayne, D Korbie, L Kenchington, B Ezzy… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… CpG sites are predictive of age [7]. These studies have constructed what is often referred to as epigenetic clocks and can be used to predict chronological or biological age [8–11]. …