[HTML][HTML] Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

J Teeuw, APS Ori, RM Brouwer, SMC de Zwarte… - Schizophrenia …, 2021 - Elsevier
… density maps in standardized space and used to predict individuals' brain age. In brief, the
predictor uses a model that predicts chronological age based on the weighted sum of whole …

Current perspectives on the cellular and molecular features of epigenetic ageing

K Raj, S Horvath - Experimental Biology and Medicine, 2020 - journals.sagepub.com
… The resulting “epigenetic clock” is a multivariate predictor of age (or alternatively mortality
risk) based on a multivariate regression model that incorporates methylation values of …

[HTML][HTML] A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

M Levine, RA McDevitt, M Meer, K Perdue… - Elife, 2020 - elifesciences.org
… key epigenetic age changes and developed a novel rat epigenetic clock, which we show
tracks age … By applying elastic net regression to the training set, we built an age predictor that …

[HTML][HTML] Hibernation slows epigenetic ageing in yellow-bellied marmots

GM Pinho, JGA Martin, C Farrell, A Haghani… - Nature ecology & …, 2022 - nature.com
… of epigenetic age with time, where the epigenetic age increased at … predict that epigenetic
ageing is faster during the active season and slower during hibernation. We test this prediction

Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging

C Kerepesi, B Zhang, SG Lee, A Trapp… - Science advances, 2021 - science.org
… The new clock is capable of predicting the epigenetic age of reduced representation bisulfite
… (r ≥ 0.8) in age prediction of test samples and were sensitive to age-related conditions and …

Accelerated epigenetic age and cognitive decline among urban-dwelling adults

MA Beydoun, D Shaked, SM Tajuddin, J Weiss… - Neurology, 2020 - AAN Enterprises
Epigenetic modifications are closely linked with aging, but … in epigenetic aging, we explored
sex-specific associations of 3 DNA methylation (DNAm)–based measures of epigenetic age

[HTML][HTML] Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk

T Wang, SK Maden, GE Luebeck, CI Li… - … epigenetics, 2020 - Springer
age of each sample and assessed for epigenetic age acceleration in the samples by regressing
the estimated biological age on the individual’s chronological agepredict a variety of age

[HTML][HTML] The relationship between epigenetic age and the hallmarks of aging in human cells

S Kabacik, D Lowe, L Fransen, M Leonard, SL Ang… - Nature aging, 2022 - nature.com
Epigenetic clocks are mathematically derived age estimators that are based on … change
with age at specific CpGs in the genome. These clocks are widely used to measure the age of …

Relationship between 5 epigenetic clocks, telomere length, and functional capacity assessed in older adults: cross-sectional and longitudinal analyses

VM Vetter, CH Kalies, Y Sommerer… - The Journals of …, 2022 - academic.oup.com
… DNAmAA was able to predict impairment in the analyzed … epigenetic age estimates, DNA
methylation age (DNAm age) and particularly its deviation from chronological age, DNAm age

[HTML][HTML] A DNA methylation age predictor for zebrafish

B Mayne, D Korbie, L Kenchington, B Ezzy… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… CpG sites are predictive of age [7]. These studies have constructed what is often referred
to as epigenetic clocks and can be used to predict chronological or biological age [8–11]. …