Epigenetic changes during ageing and their underlying mechanisms

DL Braga, F Mousovich-Neto, G Tonon-da-Silva… - Biogerontology, 2020 - Springer
… In line with this, the general aim of this Review is to highlight how epigenetic mechanisms
are involved in ageing and longevity. Epigenetic alterations are considered one of the …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
… overexpressed or mutated increase the lifespan by controlling aging and longevity [40]. On
the other hand, these age-dependent alterations produce an increased genomic instability, a …

Genetic and epigenetic mechanisms of longevity in forest trees

AY Batalova, KV Krutovsky - International Journal of Molecular Sciences, 2023 - mdpi.com
… In this review, we have focused on the genetic aspects of longevity of a few well-studied …
traits associated with plant longevity. A key trait associated with plant longevity is the enhanced …

Drosophila as a Model Organism to Study Basic Mechanisms of Longevity

AA Ogienko, ES Omelina, OV Bylino, MA Batin… - International Journal of …, 2022 - mdpi.com
… of epigenetic mechanisms of gene regulation result in agingaging. Thus, Drosophila
turned out to be a convenient object for studying epigenetic mechanisms of longevity and aging

Analysis of epigenetic age acceleration and healthy longevity among older US women

P Jain, AM Binder, B Chen, H Parada… - JAMA network …, 2022 - jamanetwork.com
longevity among older women and may be used for risk stratification and risk estimation of
future functional and cognitive aging. … to lower disease burden while increasing longevity. …

[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity

B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
epigenetic modifications. Recently, reprogramming-induced rejuvenation strategies have
begun to greatly alter longevity research not only to tackle age-… the major epigenetic changes …

Epigenetic regulation of aging: implications for interventions of aging and diseases

K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
epigenetic mechanisms in aging will provide new avenues to develop strategies to delay
aging… Another exemplary study is the discovery of resveratrol, an agonist of the longevity factor …

[HTML][HTML] An evolutionary perspective of lifespan and epigenetic inheritance

MT Mc Auley - Experimental Gerontology, 2023 - Elsevier
… to reconcile lifespan/longevity associated inherited epigenetic processes with the … longevity
of F0 flies and their F2 offspring. E(z)-mediated H3K27me3 is one epigenetic mechanism

Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging

A Li, Z Koch, T Ideker - Journal of internal medicine, 2022 - Wiley Online Library
… clock biomarker in addition to, or instead of, traditional clinical biomarkers, epigenetic age
has been used to assess the effect of purported longevity-promoting interventions including …

Multi-omic underpinnings of epigenetic aging and human longevity

LA Mavromatis, DB Rosoff, AS Bell, J Jung… - Nature …, 2023 - nature.com
… circulating metabolites on multivariate longevity and epigenetic aging, we performed a
metabolome-wide MR analysis of 249 circulating metabolites 26 on our aging-related phenotypes …