… and drug resistance. With a widely distributed expression across different cell types, ABCG2
… However, ABCG2 expression is subjected to alterations under various pathophysiological …

… improve pharmacotherapeutic outcomes by enhancing the efficacy and reducing the toxicity
of drugs that are substrates of this efflux transporter. … of 17ß-estradiol increases steadily over …

… increasing drug resistance [14,15,16]. Since estrogen can regulate the expression of ABCG2
in … could pump chemotherapeutic drugs out of tumor cells, and estradiol enhanced this …

… 182,780 significantly enhanced ABCG2 expression in tamoxifen-… that estrogenic effects are
mediated by nuclear estrogen … the protein expression of ABCG2 and Ki-67 in the drug-treated …

… (or ABCG2), the second member of the ABCG subfamily [94]. … -estradiol (E2) upregulated
the expression of Mdr1b gene … that this estrogenic compound also promotes the interaction of …

… ) transporter ABCG2 contributes to MLN4924 drug resistance … to increasing concentrations
of MLN4924 until significant drug … most upregulated genes (112-fold increase) was ABCG2 (…

… enhance drug resistance by increasing ABCB1 expression through the MAPK/ERK pathway.
… ABCG2 is implicated in both drug resistance and predicting the outcome of BC patients. In a …

… Estrogen enhances the expression of the multidrug transporter gene ABCG2—increasing
drug resistance of breast cancer cells through estrogen receptors. Int J Mol Sci . 2017;18(1):…

… of enhanced E1-S metabolism and increased E1 and E2 … the local estrogen formation and
intracrine estrogen action in … of expression of 84 human drug transporter genes, including …

… , estradiol, and testosterone on the relative content of ABCG2 in … involved in the
pharmacokinetics of drugs (for example, … an increase in the content of the ABCG2 transporter …