… We further propose a robust and economical fragment-based method to obtain overall
activation barriers, by combining the covalent activation barrier calculated for a small molecular …

… Fragment-based drug design (FBDD) is a promising methodology to find quality drug leads.
It is … provides the basis for the fragment-based design of novel strobilurin fungicide leads. …

… Here, we devise a technology that leverages fragment-based screening and SHAPE-MaP
RNA structure probing to discover small-molecule fragments that bind an RNA structure of …

… We present a fragment-based decomposition analysis tool (FB-REDA) for the
reorganisation energy (λ). This tool delivers insights on how to rationally design low-λ organic …

… In this work, we used fragment-based drug discovery approach to improve our coumarin
series. First, we screened about 200 fragments for the S1 pocket. The S1 pocket of trypsin-like …

… Herein, we report the successful application of a fragment-based approach toward the
discovery of selective Class I PRMT inhibitors. Structure-based ligand optimization was performed …

… substrate scope of our study precludes conclusions on the general application of
fragment-based phasing to MicroED data, our results demonstrate that fragment-based phasing is …

… Fragment-based drug design has become an important and … Fragment screening is very
important for fragment-based drug … Another challenge of fragment-based drug design was that …

We tackle the image reassembly problem with wide space between the fragments, in such a
way that the patterns and colors continuity is mostly unusable. The spacing emulates the …